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PROTAC Selection

Cat. No. Product name CAS No. Purity Chemical Structure
T61477 DCeMM2 296771-07-8 99.68%
dCeMM2
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K...
T17977 Fmoc-PEA 329223-23-6 99.58%
Fmoc-PEA
Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
T67778 DCeMM1 118719-16-7 99.52%
dCeMM1
dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells....
T10526 β-NF-JQ1 2380000-55-3 99.45%
β-NF-JQ1
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BR...
T31221L DBRD9 HCl 2341840-98-8 99.37%
dBRD9 HCl
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degra...
T5436 MZ 1 1797406-69-9 99.31%
MZ 1
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
T67843 GSK215 2743427-26-9 99.3%
GSK215
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
T18787 TD-165 2305936-56-3 99.24%
TD-165
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
T39370 Tri-GalNAc-COOH 1953146-81-0 99.13%
tri-GalNAc-COOH
Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T15178 DTRIM24 2170695-14-2 99.13%
dTRIM24
dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
T13722 Homo-PROTAC pVHL30 degrader 1 2244684-49-7 98.95%
Homo-PROTAC pVHL30 degrader 1
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
T4495 DBET1 1799711-21-9 98.79%
dBET1
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
T5130 DBET6 1950634-92-0 98.76%
dBET6
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T16153 MS4078 2229036-62-6 98.74%
MS4078
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
T17350 ACBI1 2375564-55-7 98.15%
ACBI1
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
T35478 Cis VH 032, amine dihydrochloride 2376990-32-6 98.03%
cis VH 032, amine dihydrochloride
cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
T5442 A1874 2064292-12-0 98%
A1874
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
T13721 Homo-PROTAC cereblon degrader 1 2244520-98-5 98%
Homo-PROTAC cereblon degrader 1
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
T5395 BSJ-03-123 2361493-16-3 97.78%
BSJ-03-123
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
T5434 ARV-825 1818885-28-7 97.54%
ARV-825
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
dCeMM2
T61477
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K...
Fmoc-PEA
T17977
Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
dCeMM1
T67778
dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells....
β-NF-JQ1
T10526
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BR...
dBRD9 HCl
T31221L
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degra...
MZ 1
T5436
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
GSK215
T67843
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
TD-165
T18787
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
tri-GalNAc-COOH
T39370
Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
dTRIM24
T15178
dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
Homo-PROTAC pVHL30 degrader 1
T13722
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
dBET1
T4495
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
dBET6
T5130
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
MS4078
T16153
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
ACBI1
T17350
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
cis VH 032, amine dihydrochloride
T35478
cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
A1874
T5442
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Homo-PROTAC cereblon degrader 1
T13721
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
BSJ-03-123
T5395
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
ARV-825
T5434
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
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