T61477 |
DCeMM2
|
296771-07-8
|
99.68%
|
|
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K...
|
T17977 |
Fmoc-PEA
|
329223-23-6
|
99.58%
|
|
Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
|
T67778 |
DCeMM1
|
118719-16-7
|
99.52%
|
|
dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells....
|
T10526 |
β-NF-JQ1
|
2380000-55-3
|
99.45%
|
|
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BR...
|
T31221L |
DBRD9 HCl
|
2341840-98-8
|
99.37%
|
|
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degra...
|
T5436 |
MZ 1
|
1797406-69-9
|
99.31%
|
|
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
|
T67843 |
GSK215
|
2743427-26-9
|
99.3%
|
|
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
|
T18787 |
TD-165
|
2305936-56-3
|
99.24%
|
|
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
|
T39370 |
Tri-GalNAc-COOH
|
1953146-81-0
|
99.13%
|
|
Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
|
T15178 |
DTRIM24
|
2170695-14-2
|
99.13%
|
|
dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
|
T13722 |
Homo-PROTAC pVHL30 degrader 1
|
2244684-49-7
|
98.95%
|
|
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
|
T4495 |
DBET1
|
1799711-21-9
|
98.79%
|
|
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
|
T5130 |
DBET6
|
1950634-92-0
|
98.76%
|
|
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
|
T16153 |
MS4078
|
2229036-62-6
|
98.74%
|
|
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
|
T17350 |
ACBI1
|
2375564-55-7
|
98.15%
|
|
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
|
T35478 |
Cis VH 032, amine dihydrochloride
|
2376990-32-6
|
98.03%
|
|
cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
|
T5442 |
A1874
|
2064292-12-0
|
98%
|
|
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
|
T13721 |
Homo-PROTAC cereblon degrader 1
|
2244520-98-5
|
98%
|
|
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
|
T5395 |
BSJ-03-123
|
2361493-16-3
|
97.78%
|
|
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
|
T5434 |
ARV-825
|
1818885-28-7
|
97.54%
|
|
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
|