T10485 |
PROTAC Bcl2 degrader-1
|
2378801-85-3
|
98%
|
|
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
|
T12027 |
MG-277
|
T12027
|
98%
|
|
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
|
T13844 |
PROTAC K-Ras Degrader-1
|
2378258-52-5
|
98%
|
|
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
|
T18597 |
DFKBP-1
|
1799711-22-0
|
98%
|
|
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
|
T17996 |
VH032-PEG5-C6-Cl
|
1799506-06-1
|
98%
|
|
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of...
|
T18632 |
PROTAC MDM2 Degrader-2
|
2249944-99-6
|
98%
|
|
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2,...
|
T17995 |
Halo PROTAC 1
|
2241668-45-9
|
98%
|
|
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce au...
|
T5439 |
BRD4 degrader AT1
|
2098836-45-2
|
98%
|
|
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
|
T10875 |
CP5V
|
2509359-75-3
|
98%
|
|
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ...
|
T18598 |
PROTAC BRD2/BRD4 degrader-1
|
T18598
|
98%
|
|
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly sel...
|
T13685 |
ERD-308
|
2320561-35-9
|
98%
|
|
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM an...
|
T11441 |
GNE-987
|
2417371-71-0
|
98%
|
|
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
|
T18682 |
SJFδ
|
2254609-23-7
|
98%
|
|
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
|
T18061 |
KB02-SLF
|
T18061
|
98%
|
|
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, a...
|
T13552 |
ARD-266
|
T13552
|
98%
|
|
ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positi...
|
T13694 |
FKBP12 PROTAC RC32
|
2375555-66-9
|
98%
|
|
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTA...
|
T41180 |
JQAD1
|
2417097-18-6
|
99.75%
|
|
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
|
T29106 |
VH032
|
1448188-62-2
|
99.72%
|
|
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
|
T5435 |
ARV-771
|
1949837-12-0
|
99.69%
|
|
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
|
T17069 |
THAL-SNS-032
|
2139287-33-3
|
99.68%
|
|
THAL-SNS-032 is a selective CDK9 degrader PROTAC.
|