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PROTAC Selection

Cat. No. Product name CAS No. Purity Chemical Structure
T10485 PROTAC Bcl2 degrader-1 2378801-85-3 98%
PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
T12027 MG-277 T12027 98%
MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
T13844 PROTAC K-Ras Degrader-1 2378258-52-5 98%
PROTAC K-Ras Degrader-1
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T18597 DFKBP-1 1799711-22-0 98%
dFKBP-1
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T17996 VH032-PEG5-C6-Cl 1799506-06-1 98%
VH032-PEG5-C6-Cl
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of...
T18632 PROTAC MDM2 Degrader-2 2249944-99-6 98%
PROTAC MDM2 Degrader-2
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2,...
T17995 Halo PROTAC 1 2241668-45-9 98%
Halo PROTAC 1
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce au...
T5439 BRD4 degrader AT1 2098836-45-2 98%
BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
T10875 CP5V 2509359-75-3 98%
CP5V
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ...
T18598 PROTAC BRD2/BRD4 degrader-1 T18598 98%
PROTAC BRD2/BRD4 degrader-1
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly sel...
T13685 ERD-308 2320561-35-9 98%
ERD-308
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM an...
T11441 GNE-987 2417371-71-0 98%
GNE-987
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
T18682 SJFδ 2254609-23-7 98%
SJFδ
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
T18061 KB02-SLF T18061 98%
KB02-SLF
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, a...
T13552 ARD-266 T13552 98%
ARD-266
ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positi...
T13694 FKBP12 PROTAC RC32 2375555-66-9 98%
FKBP12 PROTAC RC32
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTA...
T41180 JQAD1 2417097-18-6 99.75%
JQAD1
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
T29106 VH032 1448188-62-2 99.72%
VH032
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
T5435 ARV-771 1949837-12-0 99.69%
ARV-771
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
T17069 THAL-SNS-032 2139287-33-3 99.68%
THAL-SNS-032
THAL-SNS-032 is a selective CDK9 degrader PROTAC.
PROTAC Bcl2 degrader-1
T10485
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
MG-277
T12027
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
PROTAC K-Ras Degrader-1
T13844
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
dFKBP-1
T18597
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
VH032-PEG5-C6-Cl
T17996
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of...
PROTAC MDM2 Degrader-2
T18632
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2,...
Halo PROTAC 1
T17995
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce au...
BRD4 degrader AT1
T5439
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
CP5V
T10875
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ...
PROTAC BRD2/BRD4 degrader-1
T18598
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly sel...
ERD-308
T13685
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM an...
GNE-987
T11441
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
SJFδ
T18682
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
KB02-SLF
T18061
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, a...
ARD-266
T13552
ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positi...
FKBP12 PROTAC RC32
T13694
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTA...
JQAD1
T41180
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
VH032
T29106
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
ARV-771
T5435
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
THAL-SNS-032
T17069
THAL-SNS-032 is a selective CDK9 degrader PROTAC.
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