T13834 |
PROTAC BRD4 Degrader-2
|
2185795-53-1
|
98%
|
|
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
|
T11975 |
PROTAC Mcl1 degrader-1
|
2163793-38-0
|
98%
|
|
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide t...
|
T18636 |
PROTAC ERα Degrader-1
|
T18636
|
98%
|
|
PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as ...
|
T13786 |
MZP-55
|
2010159-48-3
|
98%
|
|
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
|
T13657 |
DMCL1-2
|
2351218-88-5
|
98%
|
|
dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptos...
|
T12552 |
PROTAC CDK2/9 Degrader-1
|
2408641-24-5
|
98%
|
|
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
|
T18604 |
PROTAC CRBN Degrader-1
|
2358775-70-7
|
98%
|
|
PROTAC CRBN Degrader-1 is a chemical compound consisting of a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. It fun...
|
T18680 |
SD-36
|
2429877-44-9
|
98%
|
|
SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-...
|
T13887 |
SJF620
|
2376187-16-3
|
98%
|
|
SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).
|
T13782 |
MS432
|
T13782
|
98%
|
|
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
|
T17543 |
BI-3663
|
2341740-84-7
|
98%
|
|
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3...
|
T13105 |
TD-428
|
T13105
|
98%
|
|
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
|
T17926 |
(S,R,S)-AHPC-PEG6-C4-Cl
|
1835705-59-3
|
98%
|
|
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capa...
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T13840 |
PROTAC FAK degrader 1
|
2301916-69-6
|
98%
|
|
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
|
T13930 |
TL13-12
|
2229037-04-9
|
98%
|
|
TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
|
T13833 |
PROTAC BRD4 Degrader-1
|
2133360-00-4
|
98%
|
|
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
|
T13743 |
JH-XI-10-02
|
2209085-22-1
|
98%
|
|
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
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T13845 |
PROTAC PARP1 degrader
|
2369022-68-2
|
98%
|
|
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μ...
|
T12907 |
SIAIS178
|
2376047-73-1
|
98%
|
|
SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
|
T14318 |
ARCC-4
|
1973403-00-7
|
98%
|
|
ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrad...
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