T13929 |
TL13-112
|
2229037-19-6
|
98%
|
|
TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
|
T11291 |
FKBP12 PROTAC dTAG-13
|
2064175-41-1
|
98%
|
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al...
|
T12555 |
PROTAC FLT-3 degrader 1
|
2230826-81-8
|
98%
|
|
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
|
T13850 |
PROTAC BET degrader-3
|
T13850
|
98%
|
|
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
|
T18606 |
PROTAC ER Degrader-2
|
T18606
|
98%
|
|
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequent...
|
T17728 |
PROTAC CDK9 degrader-2
|
T17728
|
98%
|
|
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogoni...
|
T12554 |
PROTAC EED degrader-2
|
T12554
|
98%
|
|
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
|
T17297 |
ZXH-3-26
|
2243076-67-5
|
98%
|
|
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
|
T13561 |
AT6
|
2098836-50-9
|
98%
|
|
AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.
|
T18609 |
PROTAC ERRα Degrader-2
|
2306388-85-0
|
98%
|
|
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This comp...
|
T13781 |
MS4077
|
2230077-10-6
|
98%
|
|
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
|
T18681 |
SJFα
|
2254609-27-1
|
98%
|
|
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the o...
|
T18634 |
PROTAC MDM2 Degrader-4
|
2249750-24-9
|
98%
|
|
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E...
|
T12553 |
PROTAC EED degrader-1
|
T12553
|
98%
|
|
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
|
T18610 |
PROTAC FKBP Degrader-3
|
2079056-43-0
|
98%
|
|
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrade...
|
T15484 |
HJB97
|
2093391-24-1
|
98%
|
|
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
|
T18060 |
KB02-JQ1
|
T18060
|
98%
|
|
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or...
|
T12798 |
(S)-GNE-987
|
T12798
|
98%
|
|
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
|
T13627 |
CP-10
|
2366268-80-4
|
98%
|
|
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
|
T12559 |
PROTAC BET degrader-2
|
2093388-33-9
|
98%
|
|
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
|