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A1874

Name: A1874
Brand: TargetMol
SKU: T5442
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5442Cas No. 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

A1874

🥰Excellent

Purity: 99.52%

Catalog No. T5442Cas No. 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$198	In Stock
10 mg	$372	In Stock
25 mg	$619	In Stock
50 mg	$1,090	In Stock
100 mg	$1,780	In Stock
200 mg	$2,430	In Stock

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Batch Information

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Purity:99.52%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

Chemical Properties

Molecular Weight	1173.59
Formula	C₅₈H₆₂Cl₃F₂N₉O₇S
Cas No.	2064292-12-0
Smiles	C(#N)[C@]1([C@H]([C@H](C(NC2=C(OC)C=C(C(NCCOCCOCCOCCNC(C[C@H]3C=4N(C5=C(C(=N3)C6=CC=C(Cl)C=C6)C(C)=C(C)S5)C(C)=NN4)=O)=O)C=C2)=O)N[C@H]1CC(C)(C)C)C7=C(F)C(Cl)=CC=C7)C8=C(F)C=C(Cl)C=C8
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (127.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8521 mL	4.2604 mL	8.5209 mL	42.6043 mL
5 mM	0.1704 mL	0.8521 mL	1.7042 mL	8.5209 mL
10 mM	0.0852 mL	0.4260 mL	0.8521 mL	4.2604 mL
20 mM	0.0426 mL	0.2130 mL	0.4260 mL	2.1302 mL
50 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.8521 mL
100 mM	0.0085 mL	0.0426 mL	0.0852 mL	0.4260 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc