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Chromatin/Epigenetic Epigenetic Reader Domain A1874

A1874

Catalog No. T5442   CAS 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

A1874, CAS 2064292-12-0
Pack Size Availability Price/USD Quantity
1 mg In Stock 200.00
2 mg In stock 310.00
5 mg In stock 590.00
10 mg In stock 860.00
25 mg In stock 1752.00
1 mL * 10 mM (in DMSO) In stock 1100.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Targets&IC50 BRD4 ,   BRD4;PROTAC
Molecular Weight 1173.59
Formula C58H62Cl3F2N9O7S
CAS No. 2064292-12-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 150 mg/mL (127.81 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hines J, Lartigue S, Dong H.et.al.MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53[J].Cancer Res. 2019 Jan 1;79(1):251-262.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library Epigenetics Compound Library PPI Inhibitors Library Anti-COVID-19 Compound Library ACE2-Targeted compound library (CADD) nsp16-Targeted compound library (CADD) X Domain-Targeted compound library (CADD)

Related Products

Related compounds with same targets
MS7972 TTK21 MS402 Zinc Protoporphyrin XD14 NEO2734 ARV-825 (+)-JQ1 PA

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