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A1874

Catalog No. T5442 CAS 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

A1874, CAS 2064292-12-0

Pack Size	Availability	Price/USD
1 mg	In Stock	200.00
2 mg	In stock	310.00
5 mg	In stock	590.00
10 mg	In stock	860.00
25 mg	In stock	1752.00
1 mL * 10 mM (in DMSO)	In stock	1100.00

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Purity 98.00%

HNMR COA Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Targets&IC50	BRD4, BRD4;PROTAC,

Molecular Weight	1173.59
Formula	C58H62Cl3F2N9O7S
CAS No.	2064292-12-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 150 mg/mL (127.81 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Hines J, Lartigue S, Dong H.et.al.MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53[J].Cancer Res. 2019 Jan 1;79(1):251-262.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.