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Inhibitory Antibodies

A monoclonal antibody is secreted by a single B lymphocyte clone which can only produce a kind of proprietary antibody against an antigen-determining cluster, and has the characteristics of single biological activity and particular specificity of binding with antigen.

The active sites of monoclonal antibody drugs involve a variety of tumor-related signaling pathways and targets. For example, the most common targets are epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor -2 (her-2 /neu, or egfr-2). Besides, there is a group of targets that are getting a lot of attention called “immune checkpoints”.

After the activation of immune cells that regulate the anti-tumor immune response, a variety of highly expressed receptors on the surface of immune cells bind to the highly expressed ligands on the surface of tumor cells to reduce the strength of the immune response, thus down-regulating the intensity of tumor-related immune response. These immunoregulatory sites are known as immune checkpoints. Currently, the most widely studied immune checkpoints are PD-1, PD-L1, and CTLA-4.

Targetmol provides xnum monoclonal antibody drugs, including the above immune checkpoint inhibitors and other types of targeted antibody inhibitors, for scientific research only.

Cat. No. Product name CAS No. Purity Chemical Structure
T35397 Sacituzumab 1796566-95-4 98%
Sacituzumab
Sacituzumab is a humanized IgG1 monoclonal antibody, a naked antibody to Sacituzumab govitecan be used to synthesize antibody-active small-molecule couplings.Sac...
T11126 Durvalumab 1428935-60-7 98%
Durvalumab
Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and ...
T77359 Tezepelumab 1572943-04-4 98%
Tezepelumab
Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor. Tezepelumab ca...
T77362 Vorsetuzumab 1165740-62-4 98%
Vorsetuzumab
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody. Vorsetuzumab has anticancer activity and can enhance th...
T77364 Sibeprenlimab 2382896-07-1 98%
Sibeprenlimab
Sibeprenlimab (VIS649) is a humanized IgG 2 monoclonal antibody that suppresses APRIL. Sibeprenlimab has an inhibitory effect on APRIL and may be studied for the...
T77367 Urelumab 934823-49-1 98%
Urelumab
Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell kil...
T77369 Telazorlimab 2126777-87-3 98%
Telazorlimab
Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat l...
T77370 Ianalumab 1929549-92-7 98%
Ianalumab
Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protecti...
T77372 Tisotumab 1418628-81-5 98%
Tisotumab
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody against tissue factor (TF). Tisotumab is involved in antibody-conjugating drug...
T77373 Concizumab 1312299-39-0 98%
Concizumab
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the i...
T77374 Ontuxizumab 946415-62-9 98%
Ontuxizumab
Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD24...
T77379 Bexmarilimab 2259301-27-2 98%
Bexmarilimab
Bexmarilimab (FP-1305) is a highly potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab promotes immune conversion of tumor-a...
T77385 Idactamab 2245205-37-0 98%
Idactamab
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
T77392 Pepinemab 2097151-87-4 98%
Pepinemab
Pepinemab(VX 15/2503) is a humanized IgG4 monoclonal antibody targeting sematone 4D. Pepinemab has anti-cancer activity and blocks the activity of SEMA4D, which ...
T77399 Crizanlizumab 1690318-25-2 98%
Crizanlizumab
Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.
T77401 Bavituximab 648904-28-3 98%
Bavituximab
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodul...
T77404 Tesnatilimab 2242758-08-1 98%
Tesnatilimab
Tesnatilimab is a potent humanized IgG4 monoclonal antibody that binds to the immune-activating receptor NKG2D. Tesnatilimab has potential immunomodulatory and a...
T77405 Enfortumab 1448664-46-7 98%
Enfortumab
Enfortumab is a monoclonal antibody against Nectin-4.Enfortumab can be used to synthesize antibody-drug couplings (enfortumab vedotin) and can also be used in co...
T77406 Lorvotuzumab 339306-30-8 98%
lorvotuzumab
Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds to CD56 (NCAM1). Lorvotuzumab can be used to synth...
T77407 Ensituximab 1092658-06-4 98%
Ensituximab
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic ...
Sacituzumab
T35397
Sacituzumab is a humanized IgG1 monoclonal antibody, a naked antibody to Sacituzumab govitecan be used to synthesize antibody-active small-molecule couplings.Sac...
Durvalumab
T11126
Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and ...
Tezepelumab
T77359
Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor. Tezepelumab ca...
Vorsetuzumab
T77362
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody. Vorsetuzumab has anticancer activity and can enhance th...
Sibeprenlimab
T77364
Sibeprenlimab (VIS649) is a humanized IgG 2 monoclonal antibody that suppresses APRIL. Sibeprenlimab has an inhibitory effect on APRIL and may be studied for the...
Urelumab
T77367
Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell kil...
Telazorlimab
T77369
Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat l...
Ianalumab
T77370
Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protecti...
Tisotumab
T77372
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody against tissue factor (TF). Tisotumab is involved in antibody-conjugating drug...
Concizumab
T77373
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the i...
Ontuxizumab
T77374
Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD24...
Bexmarilimab
T77379
Bexmarilimab (FP-1305) is a highly potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab promotes immune conversion of tumor-a...
Idactamab
T77385
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
Pepinemab
T77392
Pepinemab(VX 15/2503) is a humanized IgG4 monoclonal antibody targeting sematone 4D. Pepinemab has anti-cancer activity and blocks the activity of SEMA4D, which ...
Crizanlizumab
T77399
Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.
Bavituximab
T77401
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodul...
Tesnatilimab
T77404
Tesnatilimab is a potent humanized IgG4 monoclonal antibody that binds to the immune-activating receptor NKG2D. Tesnatilimab has potential immunomodulatory and a...
Enfortumab
T77405
Enfortumab is a monoclonal antibody against Nectin-4.Enfortumab can be used to synthesize antibody-drug couplings (enfortumab vedotin) and can also be used in co...
lorvotuzumab
T77406
Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds to CD56 (NCAM1). Lorvotuzumab can be used to synth...
Ensituximab
T77407
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic ...
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