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Durvalumab

Catalog No. T11126   CAS 1428935-60-7
Synonyms: MEDI 4736

Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells.

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Durvalumab Chemical Structure
Durvalumab, CAS 1428935-60-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 228.00
5 mg In stock $ 539.00
10 mg In stock $ 778.00
25 mg In stock $ 1,180.00
50 mg In stock $ 1,590.00
100 mg In stock $ 2,130.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells.
Targets&IC50 PD-L1/CD80:0.04 nM, PD-L1/PD-1:0.1 nM
In vivo In a mouse xenograft model of human melanoma ( A375 ) and pancreatic ( HPAC ) tumor cell lines, Durvalumab inhibits tumor growth through a T cell-mediated mechanism. Compared with the isotype-matched control antibody Durvalumab, both HPAC and A375 xenografts significantly inhibited tumor growth ( 5-0.01 mg / kg for NOD / SCID mice with HPAC tumors ; 5-0.1mg / kg for NOD / SCID mice with A375 tumor ; intraperitoneal administration ; twice a week ; for 3 weeks ), 74 % HPAC cell growth inhibition and 77 % A375 cell growth inhibition were achieved. However, when administered in the absence of T cells, Durvalumab had no effect on the growth of A375 tumor xenografts. [ 2 ]
Synonyms MEDI 4736
Molecular Weight N/A
CAS No. 1428935-60-7

Storage

store at low temperature

store at -20 ℃

TargetMolReferences and Literature

1. Faiena I, et al. Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. Drug Des Devel Ther. 2018 Jan 23;12:209-215. 2. Stewart R, et al. Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody. Cancer Immunol Res. 2015 Sep;3(9):1052-62.

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Keywords

Durvalumab 1428935-60-7 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 MEDI-4736 MEDI4736 MEDI 4736 inhibitor inhibit

 

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