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Wogonin

Catalog No. T2933   CAS 632-85-9
Synonyms: Vogonin

Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Wogonin Chemical Structure
Wogonin, CAS 632-85-9
Pack Size Availability Price/USD Quantity
20 mg In stock $ 50.00
100 mg In stock $ 140.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.8%
Purity: 99.59%
Purity: 99.43%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
In vitro Wogonin inhibits PMA-induced COX-2 gene expression by inhibiting c-Jun expression and AP-1 activation in A549 cells[1]. Wogonin is an inhibitor of cyclin-dependent kinase 9 (CDK9) and block phosphorylation of the carboxy-terminal domain of RNA polymerase II at Ser. Thus, it reduces RNA synthesis and subsequently rapid downregulation of the short-lived anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) resulting in apoptosis induction in cancer cells. Wogonin directly binds to CDK9, presumably to the ATP-binding pocketa and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity. Wogonin preferentially inhibits CDK9 in malignant compared with normal lymphocytes. Wogonin is a also potent anti-oxidant capable to scavenge ?O2? [2]. Wogonin significantly inhibits the translocation of NFATc1 from the cytoplasm to the nucleus and its transcriptional activation activity. It also significantly inhibits osteoclast differentiation and decreases the transcription of osteoclast?associated immunoglobulin?like receptor, tartrate?resistant acid phosphatase and calcitonin receptor[4]. Wogonin Inhibits N-acetyltransferase Activity[5].
In vivo Wogonin suppresses growth of human cancer xenografts in vivo. At doses lethal to tumor cells, wogonin shows no or little toxicity for normal cells and had also no obvious toxicity in animals[2]. Wogonin could induce apoptosis in murine sarcoma S180 thereby inhibiting the tumor growth both in vitro and in vivo[3]. An intraperitoneal injection of 200 mg/kg Wogonin could completely inhibit leukemia and CEM cells[4].
Cell Research A549 cells are culture in 24-well plate (1.2×105 cells/well) 1 day before wogonin treatment. DMSO or wogonin is added into A549 cells 1 h before PMA stimulation, and cells are incubated for another 6 h. Cells are collected by trypsin treatment and cell numbers are counted by using a hemocytometer and trypan blue exclusion method.(Only for Reference)
Source
Synonyms Vogonin
Molecular Weight 284.26
Formula C16H12O5
CAS No. 632-85-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

Ethanol: 3 mg/mL (10.55 mM)

TargetMolReferences and Literature

1. Chen LG, et al. Mol Nutr Food Res. 2008, 52(11):1349-57. 2. Polier G, et al. Cell Death Dis. 2011, 2:e182. 3. Wang W, et al. Biol Pharm Bull. 2006, 29(6):1132-7. 4. Geng X, et al. Exp Ther Med. 2015, 10(3):1066-1070. 5. Yu CS, et al. Anticancer Res. 2005, 25(1A):127-32. 6. Li HD, et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106. 7. Zheng Z, Zhu W, Lei L, et al. Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy[J]. Drug Design, Development and Therapy. 2020, 14: 4135-4148. 8. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.

TargetMolCitations

1. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences. 2021: 105786. 2. Zheng Z, Zhu W, Lei L, et al. Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy. Drug Design, Development and Therapy. 2020, 14: 4135-4148. 3. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.

Related compound libraries

This product is contained In the following compound libraries:
Polyphenolic Natural Product Library Miao medicine Compound Library Anti-Cancer Active Compound Library Target-Focused Phenotypic Screening Library Chinese Pharmacopoeia Natural Product Library Selected Plant-Sourced Compound Library Neural Regeneration Compound Library Anti-Prostate Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Wogonin 632-85-9 Apoptosis Autophagy Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells Wnt/beta-catenin CDK inhibit Vogonin Cyclin dependent kinase Wnt Inhibitor inhibitor

 

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