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Ursolic acid

Name: Ursolic acid
Brand: TargetMol
SKU: T0722
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0722Cas No. 77-52-1

Alias Urson, Prunol, NSC-4060, NSC 167406, Malol

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Ursolic acid

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Purity: 99.81%

Catalog No. T0722Alias Urson, Prunol, NSC-4060, NSC 167406, MalolCas No. 77-52-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$83	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ursolic acid AI Summary

Ursolic acid demonstrates a diverse range of bioactivities across multiple biological targets and cell types. It shows notable inhibitory activity against group II Phospholipase A2 (PLA2) from Vipera russelli russelli venom with an IC50 of 2.5 nM and reduces PLA2-induced edema in mice footpads. Additionally, it inhibits complement-mediated hemolysis of sensitized sheep red blood cells (IC50 = 54700.0 nM) and human complement activation (IC50 = 55000.0 nM). It also exhibits inhibitory effects on various phospholipase A2 enzymes from venoms and synovial fluid, with IC50 values ranging from 2300.0 nM to 2900.0 nM. In enzyme inhibition assays, Ursolic acid targets human recombinant PTP1B with IC50 values between 3100.0 nM to 3800.0 nM, COX2 with an IC50 of 86000.0 nM, and several other enzymes including glycogen phosphorylase A (IC50 = 9000.0 nM), DNA polymerase beta (IC50 = 18600.0 nM), and aromatase (IC50 = 32000.0 nM). Additionally, it inhibits Saccharomyces cerevisiae fatty acid synthase (IC50 = 38.0 ug/mL), USP47 (IC50 = 26000.0 nM), and alpha-amylase (IC50 = 22600.0 nM). In cellular assays, Ursolic acid shows cytotoxicity against various human cancer cell lines, including KB, A2780, HL60, HepG2, MCF7, and HeLa cells, with IC50 values indicating anti-cancer potential. It also demonstrates antiproliferative and anti-inflammatory properties, inhibiting NO production in LPS-stimulated RAW264.7 cells (IC50 = 46900.0 nM) and superoxide anion generation in neutrophils (IC50 = 600.0 nM). Ursolic acid exhibits significant antiviral activity against HIV1 (IC50 = 14300.0 nM) and HCV, as well as antiplasmodial activity against chloroquine-resistant Plasmodium falciparum (IC50 = 52930.0 nM). Additionally, it shows antituberculosis activity against Mycobacterium tuberculosis and antitrypanosomal activity against Trypanosoma brucei and Trypanosoma cruzi, with relatively high selectivity indexes. Overall, Ursolic acid is a bioactive molecule with multiple pharmacological properties, including enzyme inhibition, antiproliferative, anti-inflammatory, antiviral, and antiparasitic activities, suggesting its potential utility in various therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.
Targets&IC50	A375 cells:30.88 μM, Ca9-22 cells:5.9 μg/mL, 4T1 cells:44.08 μM, T24 cells:29.29 μM, Bcap37 cells:28.69 μM, Bel-7402 cells:64.64 μM, THP-1 cells:9.1 μM, B16 cells:3.1 μM, BGC-823 cells:> 10 μM, A549 cells:11.4 μM, ASPC1 cells:12.6 μM, CAPAN-1 cells:8.6 μM, WI-38 cells:1.8 μM, AGS cells:20.6 μM, B16 F10 cells:20.08 μM
In vitro	METHODS: Embryonal carcinoma cells NTERA-2 and NCCIT were treated with Ursolic acid (1-50 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Concentration-dependent inhibition of NTERA-2 and NCCIT cell viability by Ursolic acid treatment. [1] METHODS: Lung cancer cells H460 and H1975 were treated with Ursolic acid (5-20 nM) for 48 h. Apoptosis was detected by Flow cytometry. RESULTS: Ursolic acid significantly increased the percentage of Annexin V (+) apoptotic cells compared to control. [2]
In vivo	METHODS: To investigate the antidepressant-like effects, Ursolic acid (0.001-10 mg/kg, distilled water with 10% Tween 80) was orally administered to Swiss mice, and the TST, FST, or open-field test was performed 60 min later. RESULTS: Ursolic acid shortened the immobilization time in TST and FST.The antidepressant-like effect of Ursolic acid in TST may be mediated by the activation of dopamine D1 and D2 receptors interacting with the dopaminergic system. [3]
Synonyms	Urson, Prunol, NSC-4060, NSC 167406, Malol

Chemical Properties

Molecular Weight	456.70
Formula	C₃₀H₄₈O₃
Cas No.	77-52-1
Smiles	C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Relative Density.	1.09 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Propylene glycol: 4.76 mg/mL (10.42 mM), Sonication is recommended.

DMSO: 50.00 mg/mL (109.48 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Propylene glycol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	109.4811 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	21.8962 mL
10 mM	0.2190 mL	1.0948 mL	2.1896 mL	10.9481 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1095 mL	0.5474 mL	1.0948 mL	5.4741 mL
50 mM	0.0438 mL	0.2190 mL	0.4379 mL	2.1896 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc