Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Description | Urethane was an antineoplastic agent .Now is used for other medicinal purposes. |
Targets&IC50 | glycine receptors:46 mM(EC50), AMPA receptor:34 mM(EC50), NMDA receptors:70 mM(EC50), α4β2 nACh receptor:114 mM(EC50), GABAA receptors:64 mM(EC50) |
In vitro | urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3]. |
In vivo | Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1]. |
Synonyms | Ethyl carbamate, Carbamic acid ethyl ester, 氨基甲酸乙酯, Ethylurethane |
Molecular Weight | 89.094 |
Formula | C3H7NO2 |
CAS No. | 51-79-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (1403.08 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Urethane 51-79-6 离子通道 神经科学 微生物学 AChR Antibacterial Chloride channel GABA Receptor GluR NMDAR Parasite inhibit carbamic narcosis mutagen acid Inhibitor Bacterial Pesticide Carbamic acid ethyl ester clastogen Ethyl carbamate Ethylurethane inhibitor