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Urethane

Catalog No. T0051 CAS 51-79-6

Synonyms: Ethyl carbamate, Carbamic acid ethyl ester, 氨基甲酸乙酯, Ethylurethane

Urethane was an antineoplastic agent .Now is used for other medicinal purposes.

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Urethane, CAS 51-79-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Targets&IC50	glycine receptors:46 mM(EC50), AMPA receptor:34 mM(EC50), NMDA receptors:70 mM(EC50), α4β2 nACh receptor:114 mM(EC50), GABAA receptors:64 mM(EC50)
In vitro	urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3].
In vivo	Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1].

Synonyms	Ethyl carbamate, Carbamic acid ethyl ester, 氨基甲酸乙酯, Ethylurethane
Molecular Weight	89.094
Formula	C3H7NO2
CAS No.	51-79-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (1403.08 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Barth AM, et al. J Neurosci. 31(3):851-860. 2. Maggi CA, et al. Experientia. 1986, 42(2):109-114. 3. Hara K, et al. Anesth Analg. 2002, 94(2):313–318. 4. Xia M, Liu L, Tian C, et al. Pharmacokinetics of sinomenine hydrochloride cubic liquid crystal injection based on microdialysis technology[J]. Journal of Drug Delivery Science and Technology. 2019 Aug 52:553-558 5. Yong Z, Xingqi W, Jie H, et al. Formulation, production, in vitro release and in vivo pharmacokinetics of cinnamaldehyde sub-micron emulsions[J]. Pharmaceutical Development and Technology. 2020: 1-10. 6. Chu X, Wang X, Tian C, et al. Dual drug-loaded cubic liquid crystal gels for transdermal delivery: inner structure and percutaneous mechanism evaluations. Drug Development and Industrial Pharmacy. 2019: 1-10. 7. Xia M, Tian C, Liu L, et al. Transdermal Administration of Ibuprofen-Loaded Gel: Preparation, Pharmacokinetic Profile, and Tissue Distribution[J]. AAPS PharmSciTech. 2020, 21(3): 84.

Citations

1. Cao J, Huang J, Gui S, et al. Preparation, Synergism, and Biocompatibility of in situ Liquid Crystals Loaded with Sinomenine and 5-Fluorouracil for Treatment of Liver Cancer. International Journal of Nanomedicine. 2021, 16: 3725-3739. 2. Zhang Y, Fan X, Su Z, et al. Pretreatment with metformin prevents microcystin‐LR‐induced tau hyperphosphorylation via mTOR‐dependent PP2A and GSK‐3β activation. Environmental Toxicology. 2021 3. Liu L, Cao W, Xia M, et al. Self-Emulsifying Drug Delivery System Enhances Tissue Distribution of Cinnamaldehyde by Altering the Properties of the Mucus Layer. AAPS PharmSciTech. 2022, 23(7): 1-16. 4. Xia M, Tian C, Liu L, et al. Transdermal Administration of Ibuprofen-Loaded Gel: Preparation, Pharmacokinetic Profile, and Tissue Distribution. AAPS PharmSciTech. 2020, 21(3): 84 5. Chu X, Wang X, Tian C, et al. Dual drug-loaded cubic liquid crystal gels for transdermal delivery: inner structure and percutaneous mechanism evaluations. Drug Development and Industrial Pharmacy. 2019: 1-10 6. Yong Z, Xingqi W, Jie H, et al. Formulation, production, in vitro release and in vivo pharmacokinetics of cinnamaldehyde sub-micron emulsions. Pharmaceutical Development and Technology. 2020: 1-10 7. Xia M, Liu L, Tian C, et al. Pharmacokinetics of sinomenine hydrochloride cubic liquid crystal injection based on microdialysis technology. Journal of Drug Delivery Science and Technology. 2019 Aug 52:553-558

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Neurotransmitter Receptor Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Ion Channel Inhibitor Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library

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Keywords

Urethane 51-79-6 离子通道神经科学微生物学 AChR Antibacterial Chloride channel GABA Receptor GluR NMDAR Parasite inhibit carbamic narcosis mutagen acid Inhibitor Bacterial Pesticide Carbamic acid ethyl ester clastogen Ethyl carbamate Ethylurethane inhibitor

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