Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
200 mg | In stock | $ 31.00 | |
250 mg | In stock | $ 33.00 | |
500 mg | In stock | $ 46.00 | |
1 g | In stock | $ 53.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes. |
Targets&IC50 | AMPA receptor:34 mM(EC50), Glycine receptor:46 mM(EC50), GABAA receptor:64 mM(EC50), α4β2 nAChR:114 mM(EC50), NMDAR:70 mM(EC50) |
In vitro | urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3]. |
In vivo | Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1]. |
Synonyms | Ethyl carbamate, Ethylurethane, Carbamic acid ethyl ester |
Molecular Weight | 89.09 |
Formula | C3H7NO2 |
CAS No. | 51-79-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (1403.08 mM)
You can also refer to dose conversion for different animals. More
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Urethane 51-79-6 Membrane transporter/Ion channel Microbiology/Virology Neuroscience Chloride channel NMDAR AChR GABA Receptor Antibacterial Parasite GluR inhibit carbamic narcosis mutagen acid Ethyl carbamate Inhibitor Ethylurethane Bacterial Pesticide clastogen Carbamic acid ethyl ester inhibitor