Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 42.00 | |
50 mg | In stock | $ 53.00 | |
100 mg | In stock | $ 93.00 | |
200 mg | In stock | $ 170.00 | |
500 mg | In stock | $ 397.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor |
Targets&IC50 | EGFR:460 μM, PDGFR:0.5 μM |
In vivo | SF 6847 prevents the PDGF-induced tyrosine phosphorylation of LGF in caveolae of human fibroblasts, suggesting that PDGF-BB-mediated activation of LRP requires tyrosine phosphorylation and thereby activates PDGFR-β. Additionally, SF 6847 inhibits the replication of Herpes Simplex Virus Type 1 (HSV-1) with an IC50 of 40 nM and enhances the inclusion of MAPT exon 10 in SHSY-5Y cells by twofold at a concentration of 1.6 μM. At 1 mM, it blocks the strain-induced stimulation of DNA synthesis in fetal lung cells. SF 6847 partially reverses vanadate-induced HSV-1 plaque formation at 50 nM and reduces viral phosphoprotein phosphorylation in a dose-dependent manner at concentrations below 400 nM. However, the reduction in protein synthesis induced by SF 6847 at concentrations below 800 nM is not dose-dependent. |
Synonyms | Malonoben, Tyrphostin 9, SF 6847, AG 17, RG-50872 |
Molecular Weight | 282.38 |
Formula | C18H22N2O |
CAS No. | 10537-47-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 21.2 mg/mL (75 mM)
You can also refer to dose conversion for different animals. More
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Tyrphostin A9 10537-47-0 Angiogenesis JAK/STAT signaling Microbiology/Virology Tyrosine Kinase/Adaptors Influenza Virus EGFR VEGFR PDGFR Malonoben Tyrphostin A-9 Tyrphostin-9 Tyrphostin 9 Tyrphostin9 RG50872 inhibit Platelet-derived growth factor receptor Vascular endothelial growth factor receptor SF 6847 AG 17 AG17 SF6847 Inhibitor AG-17 Tyrphostin A 9 SF-6847 RG 50872 RG-50872 inhibitor