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Tenalisib

Name: Tenalisib
Brand: TargetMol
SKU: T13119
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13119Cas No. 1639417-53-0

Alias RP6530

Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)

Tenalisib

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Purity: 99.71%

Catalog No. T13119Alias RP6530Cas No. 1639417-53-0

Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
2 mg	$45	-	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$113	-	In Stock
25 mg	$198	-	In Stock
50 mg	$320	Inquiry	Inquiry
100 mg	$482	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$81	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)
Targets&IC50	PI3Kδ:25 nM, PI3Kγ:33 nM
In vitro	In both HEL-RS and HEL-RR cells, Tenalisib exhibits modest proliferation inhibition (33-46% inhibition @ 10 μM). Addition of 10 μM tenalisib to ruxolitinib is synergistic resulting in a near-complete inhibition of proliferation (>90% for HEL-RS and >70% for HEL-RR). Addition of 5 μM tenalisib, 4 h prior to the addition of ruxolitinib results in a significant reduction in EC50of ruxolitinib (5.8 μM) in HEL-RR cells.
In vivo	Single agent(Tenalisib) activity is evident in difficult-to-treat subjects at ≥ 200 mg BID[2].
Synonyms	RP6530

Chemical Properties

Molecular Weight	415.42
Formula	C₂₃H₁₈FN₅O₂
Cas No.	1639417-53-0
Smiles	CC[C@H](Nc1ncnc2nc[nH]c12)c1oc2ccccc2c(=O)c1-c1cccc(F)c1
Relative Density.	1.434 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (240.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4072 mL	12.0360 mL	24.0720 mL	120.3601 mL
5 mM	0.4814 mL	2.4072 mL	4.8144 mL	24.0720 mL
10 mM	0.2407 mL	1.2036 mL	2.4072 mL	12.0360 mL
20 mM	0.1204 mL	0.6018 mL	1.2036 mL	6.0180 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4072 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc