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Tempol

Catalog No. T6699 CAS 2226-96-2

Synonyms: TMPN, Tanol, 4-Hydroxy-TEMPO

Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tempol, CAS 2226-96-2

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 32.00

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Purity: 97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
In vitro	Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]
In vivo	Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]
Cell Research	The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference)

Synonyms	TMPN, Tanol, 4-Hydroxy-TEMPO
Molecular Weight	172.24
Formula	C9H18NO2
CAS No.	2226-96-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 100 mg/mL (580.59 mM ), Need ultrasound

Ethanol: 17.2 mg/mL (100 mM)

DMSO: 17.2 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mitchell JB, et al. Arch Biochem Biophys, 1991, 289(1), 62-70. 2. Gariboldi MB, et al. Free Radic Biol Med, 2000, 29(7), 633-641. 3. Chatterjee PK, et al. Kidney Int, 2000, 58(2), 658-673. 4. Pires PW, et al. Microvasc Res, 2010, 80(3), 445-452. 5. Xu H, et al. Hypertension, 2004, 43(2), 329-334. 6. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Immunology/Inflammation Compound Library Kinase Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Antioxidant Compound Library Mitochondria-Targeted Compound Library Anti-Obesity Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tempol 2226-96-2 Autophagy Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species ROS inhibit TMPN Inhibitor Tanol 4-Hydroxy-TEMPO inhibitor

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