Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 29.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 32.00 |
Description | Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects. |
In vitro | Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
In vivo | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
Cell Research | The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference) |
Synonyms | TMPN, Tanol, 4-Hydroxy-TEMPO |
Molecular Weight | 172.24 |
Formula | C9H18NO2 |
CAS No. | 2226-96-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
H2O: 100 mg/mL (580.59 mM ), Need ultrasound
Ethanol: 17.2 mg/mL (100 mM)
DMSO: 17.2 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tempol 2226-96-2 Autophagy Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species ROS inhibit TMPN Inhibitor Tanol 4-Hydroxy-TEMPO inhibitor