Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 272.00 | |
100 mg | In stock | $ 397.00 | |
500 mg | In stock | $ 936.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 58.00 |
Description | SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response. |
In vitro | SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling[1]. |
In vivo | SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30[2]. |
Synonyms | SMER 3 |
Molecular Weight | 224.18 |
Formula | C11H4N4O2 |
CAS No. | 67200-34-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (35.69 mM)
You can also refer to dose conversion for different animals. More
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SMER3 67200-34-4 Others PROTAC Ligand for E3 Ligase SMER-3 Ubiquitin activating enzyme SCF E1/E2/E3 Enzyme anticancer MET Skp1 E1 activating enzyme ligase SMER 3 Inhibitor Cullin E2 conjugating enzyme ubiquitin Ubiquitin conjugating enzyme Ubiquitin ligase E3 ligating enzyme inhibit inhibitor