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Search Results for " scf "

7

Compounds

Cat No. Product Name Synonyms Targets
T23371 SMER3 SMER 3 Others , Ligand for E3 Ligase
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...
T72043 SCFSkp2-IN-2 Apoptosis , E1/E2/E3 Enzyme
SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.
T3452 ISCK03 c-Kit
ISCK03 is a selective SCF/c-Kit inhibitor.
T17065 TFMB-(R)-2-HG Others
TFMB-(R)-2-HG is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cell differentiation in response to estrogen withdrawal.
T3317 SZL P1-41 Apoptosis , Others , E1/E2/E3 Enzyme
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...
T76919 Barzolvolimab
Barzolvolimab (CDX 0159), a humanized anti-KIT IgG1 monoclonal antibody, specifically and potently inhibits KIT activation by SCF, thereby reducing skin mast cells and disease activity in chronic inducible urticaria [1].
T71654 APcK110
APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3...
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