Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 31.00 | |
10 mg | In stock | $ 48.00 | |
25 mg | In stock | $ 64.00 | |
50 mg | In stock | $ 81.00 | |
100 mg | In stock | $ 120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 53.00 |
Description | Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer. |
In vitro | Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1]. |
Synonyms | Pyrvinium embonate |
Molecular Weight | 575.7 |
Formula | C26H28N3 . 1/2 C23H14O6 |
CAS No. | 3546-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (20.84 mM)
You can also refer to dose conversion for different animals. More
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Pyrvinium pamoate 3546-41-6 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin inhibit Pyrvinium Inhibitor Pyrvinium embonate Wnt inhibitor