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Cytoskeletal Signaling PKC Plantainoside D

Plantainoside D

Catalog No. T5796   CAS 147331-98-4
Synonyms: Isoplantamajoside, Isoplantamajoside

Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.

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Plantainoside D, CAS 147331-98-4
Pack Size Availability Price/USD Quantity
1 mg In stock 134.00
5 mg In stock 301.00
10 mg In stock 452.00
25 mg In stock 815.00
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Purity 98.00%
Purity 99.39%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.
Targets&IC50 ACE ,   PKC
In vitro Plantago asiatica L. and its major constituents(such as Plantainoside D) have ACE inhibitory activity in vitro. The identified compounds contribute to the angiotensin-converting enzyme-inhibitory activity of the extract[1].In vitro, Adriamycin(ADR) caused dose-dependent toxicity in H9c2 cardiac muscle cells. Pre-treatment of the cardiac muscle cells with Plantainoside D(PD) significantly reduced ADR-induced apoptosis of cardiac muscle cells. PD inhibited the ROS produced by ADR in the cardiac muscle cells. As well, PD increased GSH(glutathione), compared with ADR. In response to ADR, NF-kappaB was activated in H9c2 cells. However the treatment of PD reduced the activation of NF-kappaB.The NF-kappaB inhibitor, PDTC, inhibited the cytotoxic effect on ADR-induced apoptosis in cardiac muscle cells. IkappaBalpha-dominant negative plasmid-overexpression abrogated ADR-induced apoptosis in H9c2 cardiac muscle cells[2].
Kinase Assay Ethanolic extract of the seeds of Plantago asiatica L. showed significant inhibitory activity of angiotensin-converting enzyme (ACE) determined by monitoring the transformation from a substrate hippuryl-histidyl-leucine (HHL) to the product hippuric acid (HA) in vitro using an UPLC-MS method. The bioguided fractionation of the extract resulted in the isolation of four ACE inhibitory active phenylpropanoid glycosides acteoside, isoacteoside, Plantainoside D, and plantamajoside with IC(50) values of 2.69 mM, 2.46 mM, 2.17 mM, and 2.47 mM, respectively. Their structures were elucidated through the analysis of NMR, UV, IR and MS data[1].
Synonyms Isoplantamajoside , Isoplantamajoside
Purity 98.00%
Molecular Weight 640.6
Formula C29H36O16
CAS No. 147331-98-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Geng F , Yang L , Chou G , et al. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L.[J]. Phytotherapy Research, 2010, 24(7):0-0. 2. Kim D S , Woo E R , Chae S W , et al. Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-κB activation[J]. Life Sciences, 2007, 80(4):0-323.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Natural Product Library for HTS Anti-Cancer Compound Library Endocrinology-Hormone Compound Library Oxidation-Reduction Compound Library Selected Plant-Sourced Compound Library Kinase Inhibitor Library GPCR Compound Library Polyphenolic Natural Product Library Anti-Aging Compound Library Anti-Tumor Natural Product Library Chinese Pharmacopoeia Natural Product Library Ferroptosis Compound Library Anti-COVID-19 Compound Library Anti-COVID-19 Compound Library (CADD) ACE2-Targeted Compound Library (CADD) Nsp16-Targeted Compound Library (CADD) RdRP-Targeted Compound Library (CADD) Traditional Chinese Medicine Monomer Library Cytoskeletal Signaling Pathway Compound Library

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