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Chromatin/Epigenetic Sirtuin Nicotinamide

Nicotinamide

Catalog No. T0934   CAS 98-92-0
Synonyms: Nicotinic acid amide, Vitamin B3, Niacinamide, Vitamin PP

Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

Nicotinamide, CAS 98-92-0
Pack Size Availability Price/USD Quantity
5 mg In stock 16.00
10 mg In stock 20.00
25 mg In stock 30.00
50 mg In stock 38.00
100 mg In stock 43.00
200 mg In stock 50.00
500 mg In stock 60.00
1 g In stock 75.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Targets&IC50 SIRT,  
In vitro Nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. [1] Nicotinamide results in a twofold increase in DNA content and a threefold increase in insulin content in the fetal cells. Nicotinamide induces differentiation and maturation of human fetal pancreatic islet cells. [2] Nicotinamide regulates sirtuins by switching between deacetylation and base exchange. Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). [3] Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization in Alzheimer's disease transgenic mice, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increases acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c in Alzheimer's disease transgenic mice, both of which are linked to increased microtubule stability. [4] Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. Nicotinamide both prevents and reverses neuronal and vascular cell injury. [5]
In vivo Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels[6]. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice[7].
Animal Research
Animal Model: Mice
Synonyms Nicotinic acid amide , Vitamin B3 , Niacinamide , Vitamin PP
Purity 99.80%
Molecular Weight 122.12
Formula C6H6N2O
CAS No. 98-92-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 23 mg/mL (188.3 mM)

Ethanol: 23 mg/mL (188.3 mM)

Water: 22 mg/mL (180.2 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Bitterman KJ, et al. J Biol Chem, 2002, 277(47), 45099-45107. 2. Otonkoski T, et al. J Clin Invest, 1993, 92(3), 1459-1466. 3. Sauve AA, et al. Biochemistry, 2003, 42(31), 9249-9256. 4. Green KN, et al. J Neurosci, 2008, 28(45), 11500-11510. 5. Maiese K, et al. Trends Pharmacol Sci, 2003, 24(5), 228-232. 6. Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582 7. Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Stem cell Differentiation Compound Library Endocrinology-Hormones Library Epigenetics Compound Library FDA-approved Drug Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Killers Collection Histone Modification Research Compound Library

Related Products

Related compounds with same targets
Cambinol SRT1460 Nicotinamide riboside PROTAC Sirt2 Degrader-1 SIRT-IN-1 Sirt2-IN-1 (+)-Syringaresinol 5-O-Feruloylquinic acid

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