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Naringin

Catalog No. T0595 CAS 10236-47-2

Synonyms: Naringoside

Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.

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Naringin, CAS 10236-47-2

Pack Size	Availability	Price/USD
100 mg	In stock	$ 35.00
200 mg	In stock	$ 48.00
10 g	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
In vivo	The Lethal Dose 50 for mice:1650 mg/kg.
Cell Research	HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].
Source	Natural Products > Rutaceae > Citrus

Synonyms	Naringoside
Molecular Weight	580.53
Formula	C27H32O14
CAS No.	10236-47-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL (1.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL(156.8 mM)

References and Literature

1. Ueng YF, et al. Life Sci, 1999, 65(24), 2591-2602. 2. Schindler R, et al. J Nutr, 2006, 136(6), 1477-1482. 3. Kandhare AD, et al. Fitoterapia, 2012, 83(4), 650-659. 4. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051.

Citations

1. Chen Q Z, Li Y, Shao Y, et al. TGF-β1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells. International Journal of Oncology. 2017, 50(3): 1011-1021 2. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet. Molecules. 2019, 24(17): 3051 3. Mir-Cerdà A, Granados M, Saurina J, et al.Green Extraction of Antioxidant Compounds from Olive Tree Leaves Based on Natural Deep Eutectic Solvents.Antioxidants.2023, 12(5): 995. 4. Cho S C, Shaw S Y.Comparison of the inhibition effects of naringenin and its glycosides on LPS-induced inflammation in RAW 264.7 macrophages.Molecular Biology Reports.2024, 51(1): 56.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Drug Library Tobacco Monomer Library Anti-Cancer Active Compound Library Ferroptosis Compound Library Anti-Gastroenteritis Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library

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Keywords

Naringin 10236-47-2 Autophagy Metabolism Endogenous Metabolite P450 Mitophagy Mitochondrial Autophagy inhibit Naringoside Inhibitor Cytochrome P450 CYPs inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.