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Mexiletine hydrochloride

Catalog No. T1046   CAS 5370-01-4
Synonyms: KOE-1173 (hydrochloride), Mexiletine HCl, KO1173

Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.

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Mexiletine hydrochloride Chemical Structure
Mexiletine hydrochloride, CAS 5370-01-4
Pack Size Availability Price/USD Quantity
50 mg In stock $ 35.00
100 mg In stock $ 48.00
200 mg In stock $ 59.00
500 mg In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 98.44%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.
Synonyms KOE-1173 (hydrochloride), Mexiletine HCl, KO1173
Molecular Weight 215.72
Formula C11H18ClNO
CAS No. 5370-01-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (231.78 mM)

H2O: 21.6 mg/mL (100 mM)

TargetMolReferences and Literature

1. Mexiletine HCl

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Clinical Compound Library Anti-Cardiovascular Disease Compound Library Drug-Fragment Library Anti-Cancer Compound Library

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Keywords

Mexiletine hydrochloride 5370-01-4 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Sodium Channel AhR Na channels KO-1173 KOE 1173 KOE-1173 (hydrochloride) KOE-1173 antiarrhythmic Mexiletine Mexiletine HCl KO1173 Inhibitor KOE1173 ischemia Class IB myocardial inhibit KO 1173 Mexiletine Hydrochloride Na+ channels inhibitor

 

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