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Menaquinone-4

Catalog No. T7106 CAS 863-61-6

Synonyms: Vitamin K2, Menaquinone K4

Menaquinone-4 (Vitamin K2) is a vitamin K compound used as a hemostatic agent, and also as adjunctive therapy for the pain of osteoporosis.

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Menaquinone-4, CAS 863-61-6

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

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Description	Menaquinone-4 (Vitamin K2) is a vitamin K compound used as a hemostatic agent, and also as adjunctive therapy for the pain of osteoporosis.
In vivo	Vitamin K supplementation reversed the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice[1].
Animal Research	Forty-two male, 4-week-old C57BL/6J mice.?an automated constant-temperature humidity system was used to maintain a temperature of 23°C ± 2°C and humidity of 60% ± 3% for the animals.?The animals were provided with feed and drink ad libitum.?For environmental adaptation, the animals had 1 week of circulation, and then were provided with the experimental diet after being randomly divided into 6 groups (7 animals in each group;?randomized block design).?The AIN-93G diets consisted of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + vitamin K2 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + vitamin K2 (HF-K2).?The vitamin K1 and vitamin K2 contents were 200 mg/1,000 g, and the diet was provided in pellet form.?Food intake amount was measured every other day.?Body weight was measured once a week, and the food efficiency ratio (FER) was calculated by dividing the increased body weight from day1 to the final day by the food intake amount during the experiment period.?For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat were extracted from dead animal subjects, were washed with 0.9% NaCl, dried by filter paper, and then were weighed[1].

Synonyms	Vitamin K2, Menaquinone K4
Molecular Weight	444.65
Formula	C31H40O2
CAS No.	863-61-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20.83 mg/mL (46.85 mM)

References and Literature

1. Kim M , Na W , Sohn C . Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice[J]. Journal of Clinical Biochemistry and Nutrition, 2013, 53(2):108-113. 2. Noda S , Yamada A , Tanabe R , et al. Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells[J]. Nutrition Research, 2016:S0271531716301932.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Microbial Natural Product Library Bioactive Compound Library Anti-Tumor Natural Product Library Gut Microbial Metabolite Library Natural Product Library for HTS Mouse Metabolite Compound Library ReFRAME Related Library Human Endogenous Metabolite Compound Library Plus Bioactive Compounds Library Max

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Keywords

Menaquinone-4 863-61-6 Metabolism Others Endogenous Metabolite Menaquinone 4 Vitamin K2(MK-4) inhibit Inhibitor Menaquinone K-4 Vitamin K2 Menaquinone K 4 Menaquinone4 Menaquinone K4 inhibitor

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