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Loxoprofen sodium

Catalog No. T0463L CAS 80382-23-6

Synonyms: CS-600, CS600, Loxoprofen, CS 600

Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen sodium has anti-inflammatory and antitumor activity and can be used to treat atherosclerosis.

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Loxoprofen sodium, CAS 80382-23-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 62.00
50 mg	In stock	$ 91.00
100 mg	In stock	$ 133.00
500 mg	In stock	$ 333.00
1 g	In stock	$ 498.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 100%

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Description	Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen sodium has anti-inflammatory and antitumor activity and can be used to treat atherosclerosis.
Targets&IC50	COX-2:13.5 μM, COX-1:6.5 μM
In vitro	'Loxoprofen sodium, an anti-inflammatory prodrug, is a nonselective COX inhibitor with IC50s of 6.5 and 13.5μM for COX-1 and COX-2 in human whole blood assays, respectively.[1] Loxoprofen sodium is a non-selective cyclooxygenase inhibitor that is widely used for the research of pain and inflammation caused by chronic and transitory conditions. In addition, LOX sodium can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP).[2]'
In vivo	"Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED30s = 20.1, 0.7, and 2.79 mg/kg, respectively).[3] Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) reduces atherosclerosis in mice by reducing inflammation[4]. Loxoprofen sodium (60 μg/mL; p.o.; 24 days) suppresses mouse tumor growth by inhibiting VEGF[5]."

Synonyms	CS-600, CS600, Loxoprofen, CS 600
Molecular Weight	268.2834
Formula	C15H17NaO3
CAS No.	80382-23-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17.3 mg/mL (64.5 mM), Sonication is recommended.

H2O: 90.0 mg/mL (335.5 mM), Sonication is recommended.

References and Literature

1. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. 2. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. 3. Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993;24(1):105-110. 4. Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010;47(2):138-147. 5. Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Clinical Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Approved Drug Library

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Keywords

Loxoprofen sodium 80382-23-6 Immunology/Inflammation Neuroscience COX CS-600 CS600 Loxoprofen CS 600 inhibitor inhibit

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