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Polmacoxib

Catalog No. T21294 CAS 301692-76-2

Synonyms: CG 100649, CG100649, CG-100649

Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.

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Polmacoxib, CAS 301692-76-2

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Purity 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CG 100649, CG100649, CG-100649
Molecular Weight	361.39
Formula	C18H16FNO4S
CAS No.	301692-76-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: Insoluble

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kim SH, Margalit O, Katoh H,et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs. 2014 Aug 3. [Epub ahead of print] PubMed PMID: 25085205. 2. Youn Choi H, Jin SJ, Jung JA, et al. Effects of ketoconazole on the pharmacokinetic properties of CG100649, a novel NSAID: a randomized, open-label crossover study in healthy Korean male volunteers. Clin Ther. 2014 Jan 1;36(1):115-25. doi: 10.1016/j.clinthera.2013.12.004. PubMed PMID: 24417786. 3. Skarke C, Alamuddin N, Lawson JA, et al. Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther. 2012 Jun;91(6):986-93. doi: 10.1038/clpt.2012.3. Epub 2012 Jan 25. PubMed PMID: 22278334; PubMed Central PMCID: PMC3740579.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Neuronal Signaling Compound Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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