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Polmacoxib

Catalog No. T21294 CAS 301692-76-2

Synonyms: CG 100649, CG-100649, CG100649, CG100649,

Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.

Polmacoxib, CAS 301692-76-2

Pack Size	Availability	Price/USD
1 mg	In stock	149.00
5 mg	In stock	336.00
10 mg	In stock	504.00
25 mg	In stock	908.00
50 mg	In stock	1362.00
100 mg	In stock	2043.00
1 mL * 10 mM (in DMSO)	In stock	348.00

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Purity 98.49%

HNMR HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CG 100649 , CG-100649 , CG100649 , CG100649 ,
Purity	98.49%
Molecular Weight	361.39
Formula	C18H16FNO4S
CAS No.	301692-76-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Water: Insoluble

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kim SH, Margalit O, Katoh H,et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs. 2014 Aug 3. [Epub ahead of print] PubMed PMID: 25085205. 2. Youn Choi H, Jin SJ, Jung JA, et al. Effects of ketoconazole on the pharmacokinetic properties of CG100649, a novel NSAID: a randomized, open-label crossover study in healthy Korean male volunteers. Clin Ther. 2014 Jan 1;36(1):115-25. doi: 10.1016/j.clinthera.2013.12.004. PubMed PMID: 24417786. 3. Skarke C, Alamuddin N, Lawson JA, et al. Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther. 2012 Jun;91(6):986-93. doi: 10.1038/clpt.2012.3. Epub 2012 Jan 25. PubMed PMID: 22278334; PubMed Central PMCID: PMC3740579.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Clinical Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-aging Compound Library Drug Repurposing Library Covalent Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.