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Metabolism Carbonic Anhydrase Polmacoxib

Polmacoxib

Catalog No. T21294   CAS 301692-76-2
Synonyms: CG 100649, CG-100649, CG100649, CG100649,

Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.

Polmacoxib, CAS 301692-76-2
Pack Size Availability Price/USD Quantity
1 mg In stock 149.00
5 mg In stock 336.00
10 mg In stock 504.00
25 mg In stock 908.00
50 mg In stock 1362.00
100 mg In stock 2043.00
1 mL * 10 mM (in DMSO) In stock 348.00
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Purity 98.49%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Synonyms CG 100649 , CG-100649 , CG100649 , CG100649 ,
Purity 98.49%
Molecular Weight 361.39
Formula C18H16FNO4S
CAS No. 301692-76-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Water: Insoluble

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kim SH, Margalit O, Katoh H,et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs. 2014 Aug 3. [Epub ahead of print] PubMed PMID: 25085205. 2. Youn Choi H, Jin SJ, Jung JA, et al. Effects of ketoconazole on the pharmacokinetic properties of CG100649, a novel NSAID: a randomized, open-label crossover study in healthy Korean male volunteers. Clin Ther. 2014 Jan 1;36(1):115-25. doi: 10.1016/j.clinthera.2013.12.004. PubMed PMID: 24417786. 3. Skarke C, Alamuddin N, Lawson JA, et al. Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther. 2012 Jun;91(6):986-93. doi: 10.1038/clpt.2012.3. Epub 2012 Jan 25. PubMed PMID: 22278334; PubMed Central PMCID: PMC3740579.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Clinical Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-aging Compound Library Drug Repurposing Library Covalent Inhibitor Library

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.