store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 55.00 | |
25 mg | In stock | $ 86.00 | |
50 mg | In stock | $ 113.00 | |
100 mg | In stock | $ 197.00 | |
200 mg | In stock | $ 293.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis. |
In vitro | In purified rat peritoneal mast cells, Lodoxamide tromethamine inhibits ionophore-induced 45Ca influx with associated histamine release[1]. Lodoxamide tromethamine significantly and dose-dependently inhibits the chemotactic response of eosinophils to fMLP and to IL-5. Lodoxamide tromethamine strongly inhibits the release of eosinophil peroxidase after IgA-dependent activation and inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin to a lesser extent[4]. |
In vivo | In Ascaris-sensitized anesthetized rhesus monkeys, Lodoxamide tromethamine significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge[1]. The addition of Lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution increases oxygenation, decreases microvascular permeability, and increases compliance thereby decreasing lung reperfusion injury[2]. |
Synonyms | U-42585E |
Molecular Weight | 553.91 |
Formula | C19H28ClN5O12 |
CAS No. | 63610-09-3 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (27.1 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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Lodoxamide tromethamine 63610-09-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor U-42585E inhibitor inhibit