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Hydroxyzine dihydrochloride

Catalog No. T2200 CAS 2192-20-3

Synonyms: Hydroxyzine 2HCl

Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

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Hydroxyzine dihydrochloride Chemical Structure

Hydroxyzine dihydrochloride, CAS 2192-20-3

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100 mg	In stock	$ 48.00
500 mg	In stock	$ 59.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Targets&IC50	H1 receptor:10 nM-19 nM
In vitro	In a tail-flick test, intraperitoneal injection of 12.5 mg/kg Hydroxyzine reduced the analgesic effect of morphine in rats; however, an injection of 50 mg/kg Hydroxyzine enhanced the effect of morphine. Furthermore, 500 μM Hydroxyzine significantly decreased the steady-state concentration of etoposide by half, achieving a concentration of 0.055 μM/mL in Sprague-Dawley rats.
In vivo	At a concentration of 0.1 mM, Hydroxyzine inhibits 50% of Experimental Autoimmune Encephalomyelitis (EAE) exacerbation in Lewis rats and suppresses 70% of mast cell degranulation. In bladder slices pre-treated with Hydroxyzine, a 60-minute incubation results in a 34% inhibition of 5-hydroxytryptamine release induced by 10 μM carbachol, with 1 μM Hydroxyzine causing a 25% inhibition and 0.1 μM suppressing it by 17%. Additionally, 500 μM Hydroxyzine significantly enhances the transport of digoxin to the serosal side in isolated everted jejunum sacs and notably reduces the efflux of approximately 2.4 μg/mL digoxin in the jejunum and ileum.

Synonyms	Hydroxyzine 2HCl
Molecular Weight	447.83
Formula	C21H27ClN2O2·2HCl
CAS No.	2192-20-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 201 mM

DMSO: 201 mM

References and Literature

1. Anthes JC, et al. Eur J Pharmacol, 2002, 449(3), 229-237. 2. Minogiannis P, et al. Int J Immunopharmacol, 1998, 20(10), 553-563. 3. Dimitriadou V, et al. Int J Immunopharmacol, 2000, 22(9), 673-684. 4. Kan WM, et al. Anticancer Drugs, 2001, 12(3), 267-273. 5. Morichi R, et al. Pain, 1979, 7(2), 173-180.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library

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Keywords

Hydroxyzine dihydrochloride 2192-20-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibit Hydroxyzine itching disorder nausea Hydroxyzine Dihydrochloride Hydroxyzine 2HCl anxiety Inhibitor GAD tension inhibitor

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