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L-Canavanine sulfate

Catalog No. T5838 CAS 2219-31-0

L-Canavanine sulfate is a selective inducible NO Synthase inhibitor.

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L-Canavanine sulfate, CAS 2219-31-0

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Purity: 98%

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Description	L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
In vitro	L-Canavanine sulfate,which is hardly toxic alone, potentiated the cytotoxicity of VIN and PTX in HeLa and hepatocellular carcinoma cells[1].
In vivo	Intravenous infusion of L-canavanine (100 mg/kg), a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension. However, in lipopolysaccharide challenged animals protected from hypotension by administration of L-canavanine (60 min post challenge), intravenous infusion of NG-nitro-L-arginine methyl ester at 180 min post challenge caused an immediate rise in mean arterial pressure, followed by a rapid fall in blood pressure and heart rate, and sudden death. In contrast, a second dose of L-canavanine at 180 min post challenge maintained blood pressure for the duration of the experiment. Inhibition of both constitutive and inducible NO synthase during endotoxaemia is lethal[2].
Cell Research	The following cancer cells grown in arginine-rich and arginine-free media were employed: HeLa, Hep G2 and SK-HEP-1. Drug combination experiment used a method based on the median-effect principle and mass-action law[1].

Molecular Weight	274.25
Formula	C5H14N4O7S
CAS No.	2219-31-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 100 mg/mL (364.63 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nurcahyanti A D R , Wink M . Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells[J]. Phytomedicine, 2015, 22(14):S0944711315003190. 2. Teale D M , Atkinson A M . L-Canavanine restores blood pressure in a rat model of endotoxic shock[J]. European Journal of Pharmacology, 1994, 271(1):0-92.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Breast Cancer Compound Library Pyroptosis Compound Library NF-κB Signaling Compound Library NO PAINS Compound Library Natural Product Library HIF-1 Signaling Pathway Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Cancer Compound Library Selected Plant-Sourced Compound Library

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Keywords

L-Canavanine sulfate 2219-31-0 Immunology/Inflammation NF-Κb NO Synthase NOD Nitric oxide synthases Inhibitor inhibit L Canavanine sulfate LCanavanine sulfate L-Canavanine NOS inhibitor

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