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L-Canavanine sulfate

L-Canavanine sulfate
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L-Canavanine sulfate

Catalog No. T5838Cas No. 2219-31-0
L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
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Product Introduction

L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
In vitro
L-Canavanine sulfate,which is hardly toxic alone, potentiated the cytotoxicity of VIN and PTX in HeLa and hepatocellular carcinoma cells[1].
In vivo
Intravenous infusion of L-canavanine (100 mg/kg), a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension. However, in lipopolysaccharide challenged animals protected from hypotension by administration of L-canavanine (60 min post challenge), intravenous infusion of NG-nitro-L-arginine methyl ester at 180 min post challenge caused an immediate rise in mean arterial pressure, followed by a rapid fall in blood pressure and heart rate, and sudden death. In contrast, a second dose of L-canavanine at 180 min post challenge maintained blood pressure for the duration of the experiment. Inhibition of both constitutive and inducible NO synthase during endotoxaemia is lethal[2].
Cell Research
The following cancer cells grown in arginine-rich and arginine-free media were employed: HeLa, Hep G2 and SK-HEP-1. Drug combination experiment used a method based on the median-effect principle and mass-action law[1].
Chemical Properties
Molecular Weight274.25
Cas No.2219-31-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 100 mg/mL (364.63 mM)
Solution Preparation Table
1 mM3.6463 mL18.2315 mL36.4631 mL182.3154 mL
5 mM0.7293 mL3.6463 mL7.2926 mL36.4631 mL
10 mM0.3646 mL1.8232 mL3.6463 mL18.2315 mL
20 mM0.1823 mL0.9116 mL1.8232 mL9.1158 mL
50 mM0.0729 mL0.3646 mL0.7293 mL3.6463 mL
100 mM0.0365 mL0.1823 mL0.3646 mL1.8232 mL


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