Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 283.00 | |
25 mg | In stock | $ 512.00 | |
50 mg | In stock | $ 743.00 | |
100 mg | In stock | $ 1,050.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 212.00 |
Description | Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM). |
Targets&IC50 | 5-HT6 receptor:0.83 nM(Ki) |
In vitro | In the 5-HT(6) GTP gamma S efficacy assay, Lu AE58054 showed potent inhibition of 5-HT-mediated activation. Apart from medium affinity to adrenergic alpha (1B)- and alpha(1A)-adrenoreceptors, Lu AE58054 shows >50-fold selectivity compared with more than 70 targets examined[1]. |
In vivo | In the rats model, Orally administered Lu AE58054 inhibited binding of the 5-HT6 antagonist Lu AE60157 (ED50: 2.7 mg/kg). Administration of Lu AE58054 in a dose range (5–20 mg/kg) leading to above 65% 5-HT6R binding, which reversed cognitive impairment in rats treatment with phencyclidine. These results indicate that Lu AE58054 is a potent antagonist of 5-HT6Rs with good oral bioavailability in the rat model of cognitive impairment in schizophrenia[1]. |
Synonyms | Lu AE58054 Hydrochloride, Idalopirdine HCl |
Molecular Weight | 434.83 |
Formula | C20H20ClF5N2O |
CAS No. | 467458-02-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL(114.99 mM)
DMSO: 20 mg/mL(45.99 mM)
H2O: 3 mg/mL(6.90 mM, with ultrasonic and warming), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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Idalopirdine Hydrochloride 467458-02-2 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Receptor Lu AE58054 inhibit 5-hydroxytryptamine Receptor Lu AE-58054 Hydrochloride Lu AE58054 Hydrochloride Lu AE-58054 Lu AE 58054 Hydrochloride Lu AE 58054 Idalopirdine HCl Idalopirdine Inhibitor inhibitor