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Masupirdine free base

Catalog No. T11948   CAS 701205-60-9
Synonyms: SUVN-502 free base

Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor).

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Masupirdine free base Chemical Structure
Masupirdine free base, CAS 701205-60-9
Pack Size Availability Price/USD Quantity
25 mg In stock $ 1,520.00
50 mg In stock $ 1,980.00
100 mg In stock $ 2,500.00
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Purity: 98.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor).
Targets&IC50 5-HT6 receptor:2.04 nM (ki)
Synonyms SUVN-502 free base
Molecular Weight 478.4
Formula C21H24BrN3O3S
CAS No. 701205-60-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.

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Keywords

Masupirdine free base 701205-60-9 GPCR/G Protein Neuroscience 5-HT Receptor SUVN502 SUVN 502 Masupirdine SUVN-502 free base SUVN-502 inhibitor inhibit

 

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