store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICI 118,551 hydrochloride (ICI 118551 hydrochloride) is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | ICI 118,551 hydrochloride (ICI 118551 hydrochloride) is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors). |
Targets&IC50 | β1-adrenoceptor:49.5 nM (ki), β2-adrenoceptor:ki:0.7nM , β3-adrenoceptor:611 nM (ki) |
In vitro | ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO [2]. ICI 118551 inhibits cAMP accumulation in IMCD cells (IC50: 1.7 μM) [1]. In the failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances the negative inotropic effects of ICI 118551 [3]. |
In vivo | ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, strongly reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure in vivo[2]. |
Synonyms | ICI 118551 hydrochloride |
Molecular Weight | 313.86 |
Formula | C17H28ClNO2 |
CAS No. | 72795-01-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (63.72 mM), Sonication is recommended.
H2O: 11 mg/mL (35.05 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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