Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 387.00 | |
100 mg | In stock | $ 568.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 106.00 |
Description | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism. |
In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
Animal Research | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
Source |
Molecular Weight | 615.71 |
Formula | C33H45NO10 |
CAS No. | 6900-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (81.21 mM)
You can also refer to dose conversion for different animals. More
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