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Glabrol

Catalog No. TN1691 CAS 59870-65-4

Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.

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Glabrol, CAS 59870-65-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 249.00
10 mg	In stock	$ 422.00
25 mg	In stock	$ 686.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 276.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
Targets&IC50	ACAT (rat):24.6 μM (IC50)
In vitro	Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T[1]
Source	Natural Products > Fabaceae > Glycyrrhiza

Molecular Weight	392.49
Formula	C25H28O4
CAS No.	59870-65-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (165.61 mM)

References and Literature

1. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.Bioorg Med Chem. 2017 Jul 15;25(14):3706-3713.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Metabolite Library Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Traditional Mongolian Medicine Compound Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Flavonoid Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library

Related Products

Related compounds with same targets

Chalepensin 15-Hydroxydehydroabietic acid Naringenin Proadifen hydrochloride Enerisant HCl 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate Rosavin 8-Geranyloxypsoralen

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glabrol 59870-65-4 Immunology/Inflammation Metabolism NF-Κb NF-κB P450 NO Synthase Acyltransferase Inhibitor mono- acylglycerol acyltransferase Diacylglycerol acyltransferase inhibit Diglyceride acyltransferase acyl-CoA:cholesterol acyltransferase inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.