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JAK/STAT signaling STAT Ginkgetin

Ginkgetin

Catalog No. T4S2126   CAS 481-46-9

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.

Ginkgetin, CAS 481-46-9
Pack Size Availability Price/USD Quantity
5 mg In stock 228.00
50 mg In stock 1048.00
100 mg In stock 1572.00
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Purity 99.22%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.
Targets&IC50 COX-2
Molecular Weight 566.51
Formula C32H22O10
CAS No. 481-46-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. You O H , Kim S H , Kim B , et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2692-2695. 2. Jeon YJ, et al. Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of STAT3 activity. Cancer Sci. 2015 Jan 22. doi: 10.1111/cas.12608.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Neuronal Signaling Compound Library Immunology/Inflammation Compound Library Antibiotics Library Anti-Cardiovascular Disease Compound Library Anti-aging Compound Library Small Molecule Immuno-Oncology Compound Library Anti-Inflammatory Tradition Chinese Medicine Library Nonsteroidal Antiinflammatory Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Rare Natural Compound Library

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