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Ginkgetin

Catalog No. T4S2126   CAS 481-46-9

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.

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Ginkgetin Chemical Structure
Ginkgetin, CAS 481-46-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 120.00
1 mL * 10 mM (in DMSO) In stock $ 155.00
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Purity: 99.94%
Purity: 99.67%
Purity: 99.22%
Purity: 98.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.
Targets&IC50 COX-2:0.75 microM
Source
Molecular Weight 566.51
Formula C32H22O10
CAS No. 481-46-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (97.08 mM)

TargetMolReferences and Literature

1. You O H , Kim S H , Kim B , et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2692-2695.

TargetMolCitations

1. Tang T, Wang X, Qi E, et al. Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPARγ Pathway. Neurochemical Research. 2022: 1-12 2. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Anti-Cancer Active Compound Library Transcription Factor-Targeted Compound Library Angiogenesis related Compound Library Nonsteroidal Anti-Inflammatory Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Aging Compound Library Immuno-Oncology Compound Library Reprogramming Compound Library

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Gigantol Gossypolone NCB-0846 (E)-Ferulic acid C-82 PNU-74654 TINK-IN-1 NRX-252114

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Keywords

Ginkgetin 481-46-9 Apoptosis Autophagy Cytoskeletal Signaling Immunology/Inflammation JAK/STAT signaling Neuroscience Stem Cells Wnt/beta-catenin COX STAT anti-tumor biloba anti-fungal Ginkgo signaling Wnt neuroprotective inhibit leaves anti-inflammatory biflavone Inhibitor inhibitor

 

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