Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 73.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | Inquiry | $ 198.00 | |
50 mg | Inquiry | $ 297.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
In vitro | Gimatecan HCl (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency. Gimatecan HCl causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL)[1]. |
In vivo | Gimatecan HCl (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth [1]. |
Synonyms | ST1481 HCL, Gimatecan HCl(292618-32-7 Free base) |
Molecular Weight | 483.94 |
Formula | C25H26ClN3O5 |
CAS No. | T21319L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.84 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Gimatecan HCl T21319L DNA Damage/DNA Repair Topoisomerase ST1481 HCL Gimatecan HCl(292618-32-7 Free base) inhibitor inhibit