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SW044248

Catalog No. T3181   CAS 522650-83-5

SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.

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SW044248 Chemical Structure
SW044248, CAS 522650-83-5
Pack Size Availability Price/USD Quantity
2 mg In stock $ 37.00
5 mg In stock $ 59.00
10 mg In stock $ 97.00
25 mg In stock $ 198.00
50 mg In stock $ 378.00
100 mg In stock $ 568.00
1 mL * 10 mM (in DMSO) In stock $ 66.00
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Purity: 99.56%
Purity: 99.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
Kinase Assay The potency of JNJ-42041935 for inhibition of the structurally related enzyme FIH is assessed by methods similar to those described for PHD2. In brief, activity of FIH is determined using purified glutathione transferase-tagged full-length FIH amino acids 1 to 350 and a synthetic HIF-1α peptide corresponding to residues Asp788 to Leu822. Compounds are preincubated with 17.1 nM FIH for 30 min, followed by a 10-min incubation with 1 μM [2-14C]2-oxoglutarate, in the presence of 10 μM FeNH4SO4 in reaction buffer. The selectivity of JNJ-42041935 for inhibition of a range of other targets available for testing in commercial assays is also assessed at concentrations of 1 and 10 μM[1].
Molecular Weight 421.52
Formula C22H23N5O2S
CAS No. 522650-83-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL

TargetMolReferences and Literature

1. Zubovych IO, et al. Mol Y Ther. 2016 Jan;15(1):23-36.

Related compound libraries

This product is contained In the following compound libraries:
Target-Focused Phenotypic Screening Library Inhibitor Library Anti-Aging Compound Library Bioactive Compounds Library Max NO PAINS Compound Library DNA Damage & Repair Compound Library Bioactive Compound Library

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Keywords

SW044248 522650-83-5 DNA Damage/DNA Repair Topoisomerase inhibit SW-044248 SW 044248 Inhibitor inhibitor

 

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