Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 37.00 | |
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 378.00 | |
100 mg | In stock | $ 568.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells. |
Kinase Assay | The potency of JNJ-42041935 for inhibition of the structurally related enzyme FIH is assessed by methods similar to those described for PHD2. In brief, activity of FIH is determined using purified glutathione transferase-tagged full-length FIH amino acids 1 to 350 and a synthetic HIF-1α peptide corresponding to residues Asp788 to Leu822. Compounds are preincubated with 17.1 nM FIH for 30 min, followed by a 10-min incubation with 1 μM [2-14C]2-oxoglutarate, in the presence of 10 μM FeNH4SO4 in reaction buffer. The selectivity of JNJ-42041935 for inhibition of a range of other targets available for testing in commercial assays is also assessed at concentrations of 1 and 10 μM[1]. |
Molecular Weight | 421.52 |
Formula | C22H23N5O2S |
CAS No. | 522650-83-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL
You can also refer to dose conversion for different animals. More
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SW044248 522650-83-5 DNA Damage/DNA Repair Topoisomerase inhibit SW-044248 SW 044248 Inhibitor inhibitor