topoisomerase — TargetMol Chemicals

Cat No.	Product Name	Targets
T67899	Topoisomerase II inhibitor 13	Topoisomerase
	Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.	Topoisomerase
T77650	Topoisomerase II inhibitor 14	Apoptosis , Antioxidant , Topoisomerase , NO Synthase
	Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.Topoisomerase II inhibi...	Apoptosis , Antioxidant , Topoisomerase , NO Synthase
T78717	Topoisomerase inhibitor 2	Topoisomerase
	Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].	Topoisomerase
T60766	Topoisomerase I inhibitor 3
	Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase. Topoisomerase I inhibitor 3 is an inhibitor of topoisomerase I that interact with topoisomerase I-DNA compl...
T61017	Topoisomerase II inhibitor 6
	Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th...
T64164	Topoisomerase II inhibitor 11
	Topoisomerase II inhibitor 11 (compound 3d) is a potent inhibitor of Topoisomerase II (IC50: 2.89 μM). Topoisomerase II inhibitor 11 inhibits cell proliferation and has apoptotic activity by blocking the cell cycle in th...
T80968	Topoisomerase I inhibitor 10	Topoisomerase
	Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrates efficacy against L. donovani promastigotes with an IC50 ...	Topoisomerase
T63068	Topoisomerase II inhibitor 5
	Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.
T61283	Topoisomerase II inhibitor 3
	Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo...
T79539	Topoisomerase II inhibitor 16	Topoisomerase
	Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D...	Topoisomerase
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho...
T63594	Topoisomerase IIα-IN-3
	Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.
T62223	Topoisomerase IIα-IN-1
	Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase. topoisomerase IIα-IN-1 shows good anti-proliferative effects on human cancer cell lines.
T60781	Topoisomerase II inhibitor 8
	Topoisomerase II inhibitor 8 (compound 22) shows good anti-proliferative activities and arrest the cell cycle at G2/M phase. Topoisomerase II inhibitor 8 is a potent inhibitor of topoisomerase II (IC 50 = 0.52 μM) [1].
T80967	Topoisomerase I inhibitor 9	Topoisomerase
	Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value of 34.81μM against L. donovani promastigotes [1].	Topoisomerase
T61431	Topoisomerase IIα-IN-4
	Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon...
T72157	Topoisomerase II inhibitor 7
	Topoisomerase II inhibitor 7, a potent inhibitor of the topoisomerase II alpha subtype, exhibits an IC50 of 3.19 μM. It effectively induces cell cycle arrest and apoptosis.
T72153	Topoisomerase IV inhibitor 1	Topoisomerase
	Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for DNA gyrase. It also demonstrates antibacterial efficacy, w...	Topoisomerase
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and...