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GLPG2938

Catalog No. T9199 CAS 2130996-00-6

Synonyms: 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea

GLPG2938 is a potent and selective antagonist of S1P2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GLPG2938, CAS 2130996-00-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 578.00
50 mg	In stock	$ 833.00
100 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 179.00

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Purity: 98.1%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLPG2938 is a potent and selective antagonist of S1P2.
In vitro	GLPG2938 significantly prevents the S1P-mediated contraction at all tested concentrations[1].
In vivo	In all species ,GLPG2938 shows good pharmacokinetics, with long half-life,low clearance,and good bioavailability.

Synonyms	1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea
Molecular Weight	503.4
Formula	C20H19F6N7O2
CAS No.	2130996-00-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/ml (119.19 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis[J]. Journal of Medicinal Chemistry, 2021, 64(9):6037-6058.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max GPCR Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

ASP-4058 SLP9101555 KD-3010 VPC 23019 SK1-IN-1 PF-543 Citrate S1p receptor agonist 1 PF-543 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GLPG2938 2130996-00-6 GPCR/G Protein S1P Receptor LPL Receptor GLPG 2938 Lysophospholipid Receptor fibrosis inhibit 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea GLPG-2938 selective pulmonary Inhibitor potent idiopathic inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.