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GLPG2938

Catalog No. T9199 CAS 2130996-00-6

Synonyms: 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea

GLPG2938 is a potent and selective antagonist of S1P2.

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GLPG2938, CAS 2130996-00-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLPG2938 is a potent and selective antagonist of S1P2.
In vitro	GLPG2938 significantly prevents the S1P-mediated contraction at all tested concentrations[1].
In vivo	In all species ,GLPG2938 shows good pharmacokinetics, with long half-life,low clearance,and good bioavailability.

Synonyms	1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea
Molecular Weight	503.409
Formula	C20H19F6N7O2
CAS No.	2130996-00-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/ml (119.19 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis[J]. Journal of Medicinal Chemistry, 2021, 64(9):6037-6058.

Related Products

Related compounds with same targets

GLPG2938 ONO-7300243 GSK2018682 Ki16198 SLF1081851 PF-543 Ponesimod CYM5442

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GLPG2938 2130996-00-6 G蛋白偶联受体 LPL Receptor S1P Receptor GLPG 2938 Lysophospholipid Receptor fibrosis inhibit 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea GLPG-2938 selective pulmonary Inhibitor potent idiopathic inhibitor

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