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Chebulagic acid

Name: Chebulagic acid
Brand: TargetMol
SKU: TQ0180
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TQ0180Cas No. 23094-71-5

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Chebulagic acid

🥰Excellent

Purity: 99.8%

Catalog No. TQ0180Cas No. 23094-71-5

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Pack Size	Price	Availability
1 mg	$72	In Stock
5 mg	$168	In Stock
10 mg	$250	In Stock
25 mg	$418	In Stock
50 mg	$623	In Stock
100 mg	$887	In Stock
1 mL x 10 mM (in DMSO)	$270	In Stock

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Batch Information

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Purity:99.8%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
In vitro	Chebulagic acid can enhance autophagy and exerts anti-inflammatory and anti-infective effects [1,2]. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner [3].

Chemical Properties

Molecular Weight	954.66
Formula	C₄₁H₃₀O₂₇
Cas No.	23094-71-5
Smiles	O[C@H]1[C@H]2[C@H](CC(O)=O)C(=O)O[C@@H]3[C@H]4COC(=O)c5cc(O)c(O)c(O)c5-c5c(O)c(O)c(O)cc5C(=O)O[C@@H]3[C@@H](OC(=O)c3cc(O)c(O)c(OC1=O)c23)[C@H](OC(=O)c1cc(O)c(O)c(O)c1)O4
Relative Density.	2.13 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 98 mg/mL (102.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0475 mL	5.2375 mL	10.4749 mL	52.3747 mL
5 mM	0.2095 mL	1.0475 mL	2.0950 mL	10.4749 mL
10 mM	0.1047 mL	0.5237 mL	1.0475 mL	5.2375 mL
20 mM	0.0524 mL	0.2619 mL	0.5237 mL	2.6187 mL
50 mM	0.0209 mL	0.1047 mL	0.2095 mL	1.0475 mL
100 mM	0.0105 mL	0.0524 mL	0.1047 mL	0.5237 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc