Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 148.00 | |
10 mg | In stock | $ 217.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 779.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 160.00 |
Description | Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
Targets&IC50 | IL-6/STAT3 signaling pathway:11.56 μM (IC50) |
In vitro | Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM).?Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM).?This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway. |
Synonyms | 6-Methoxyldihydrochelerythrine |
Molecular Weight | 379.41 |
Formula | C22H21NO5 |
CAS No. | 21080-31-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/ml (79.07 mM)
You can also refer to dose conversion for different animals. More
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Angoline 21080-31-9 Immunology/Inflammation JAK/STAT signaling Stem Cells STAT IL Receptor phosphorylation proliferation STAT3 anticancer inhibit Inhibitor 6-Methoxyldihydrochelerythrine IL-6 inhibitor