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AZD-8835

Catalog No. T6774 CAS 1620576-64-8

Synonyms: AZD8835

AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).

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AZD-8835, CAS 1620576-64-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 105.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 497.00
1 mL * 10 mM (in DMSO)	In stock	$ 87.00

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Purity: 98.49%

Purity: 98.22%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).
Targets&IC50	PI3Kα:6.2 nM, PI3Kδ:5.7 nM
In vitro	AZD8835 is a potent inhibitor of PI3Kα (wild type, E545K and H1047R mutations) and PI3Kδ with excellent selectivity vs. PI3Kβ, PI3Kγ and an excellent general kinase selectivity. AZD8835 is a potent inhibitor of p-Akt in cells sensitive to PI3Kα inhibition (IC50=0.057 μM in PIK3CA mutant human breast ductal carcinoma BT474 cell line) and in cells sensitive to PI3Kδ inhibition (IC50=0.049 μM in JeKo-1 B cell line), but not to cells sensitive to PI3Kβ inhibition (IC50=3.5 μM in PTEN null breast adenocarcinoma MDA-MB-468 cell line) or PI3Kγ inhibition (IC50=0.53 μM in monocytic RAW264 cell line)[2].
In vivo	AZD8835 has antitumor efficacy in corresponding breast cancer xenograft models when dosed continuously and displays high metabolic stability and suitable physical properties for oral administration[1][2].
Cell Research	BT474, MCF7, or T47D cells are seeded in 384-well plates at a density of 500 to 2,000 cells per well and incubated overnight. Cells are dosed with compound(s) and cell confluency is measured at 4-hour intervals over several days.(Only for Reference)

Synonyms	AZD8835
Molecular Weight	469.54
Formula	C22H31N9O3
CAS No.	1620576-64-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 86 mg/mL (183.2 mM)

References and Literature

1. Hudson K, et al. Mol Cancer Ther. 2016, 15(5):877-89. 2. Bernard Barlaam, et al. Bioorganic & Medicinal Chemistry Letters. 2015, 25(22):5155-5162.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Inhibitor Library Glycometabolism Compound Library Antioxidant Compound Library NO PAINS Compound Library Stem Cell Differentiation Compound Library

Related Products

Related compounds with same targets

Buparlisib SKI V GS-9901 MSC2360844 Dalbergioidin PI3Kδ-IN-12 GDC0084 Sennidin B

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZD-8835 1620576-64-8 PI3K/Akt/mTOR signaling PI3K inhibit AZD 8835 Inhibitor AZD8835 Phosphoinositide 3-kinase inhibitor

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