Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 213.00 | |
2 mg | In stock | $ 318.00 | |
5 mg | In stock | $ 538.00 | |
10 mg | In stock | $ 778.00 | |
25 mg | In stock | $ 1,180.00 | |
50 mg | In stock | $ 1,620.00 | |
100 mg | In stock | $ 2,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 593.00 |
Description | AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis. |
Targets&IC50 | CCR5:0.32 nM (IC50), hERG:7.3 μM (IC50), hP-gp:32 μM (IC50) |
In vitro | In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1]. |
In vivo | AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3]. |
Synonyms | AZD 5672, AZD5672, UNII-61XQN688TW |
Molecular Weight | 632.78 |
Formula | C32H38F2N2O5S2 |
CAS No. | 780750-65-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (47.4 mM), ultrasonic and warming and heat to 60°C
You can also refer to dose conversion for different animals. More
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AZD-5672 780750-65-4 Angiogenesis Immunology/Inflammation JAK/STAT signaling Membrane transporter/Ion channel Microbiology/Virology Neuroscience Tyrosine Kinase/Adaptors HER P-gp CCR AZD 5672 AZD5672 UNII-61XQN688TW inhibitor inhibit