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AZD-5672

Catalog No. T30260   CAS 780750-65-4
Synonyms: AZD 5672, AZD5672, UNII-61XQN688TW

AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.

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AZD-5672 Chemical Structure
AZD-5672, CAS 780750-65-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 213.00
2 mg In stock $ 318.00
5 mg In stock $ 538.00
10 mg In stock $ 778.00
25 mg In stock $ 1,180.00
50 mg In stock $ 1,620.00
100 mg In stock $ 2,180.00
1 mL * 10 mM (in DMSO) In stock $ 593.00
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Purity: 95.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.
Targets&IC50 CCR5:0.32 nM (IC50), hERG:7.3 μM (IC50), hP-gp:32 μM (IC50)
In vitro In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1].
In vivo AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3].
Synonyms AZD 5672, AZD5672, UNII-61XQN688TW
Molecular Weight 632.78
Formula C32H38F2N2O5S2
CAS No. 780750-65-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (47.4 mM), ultrasonic and warming and heat to 60°C

TargetMolReferences and Literature

1. Elsby R, et al. The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug Metab Dispos. 2011 Feb;39(2):275-82. 2. Gerlag DM, et al. Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis Rheum. 2010 Nov;62(11):3154-60. 3. Cumming JG, et al. Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1655-9.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Lung Cancer Compound Library Bioactive Compound Library

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Keywords

AZD-5672 780750-65-4 Angiogenesis Immunology/Inflammation JAK/STAT signaling Membrane transporter/Ion channel Microbiology/Virology Neuroscience Tyrosine Kinase/Adaptors HER P-gp CCR AZD 5672 AZD5672 UNII-61XQN688TW inhibitor inhibit

 

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