Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 153.00 | |
5 mg | In stock | $ 392.00 | |
10 mg | In stock | $ 583.00 | |
25 mg | In stock | $ 937.00 | |
50 mg | In stock | $ 1,270.00 | |
100 mg | In stock | $ 1,720.00 | |
500 mg | In stock | $ 3,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 375.00 |
Description | ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells |
Targets&IC50 | KRas (G12C):2.5 μM |
In vitro | ARS-853 decreases phosphorylation of c-RAF, ERK, and Akt. ARS853 inhibits proliferation of six lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 μM), but does not inhibit proliferation of PC-9 cells, which contain wild-type K-RAS[1]. |
Molecular Weight | 432.94 |
Formula | C22H29ClN4O3 |
CAS No. | 1629268-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 71 mg/mL (164.00 mM)
You can also refer to dose conversion for different animals. More
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ARS-853 1629268-00-3 Apoptosis GPCR/G Protein MAPK Raf Ras KRAS cancer mutant state inhibit Inhibitor ARS853 inactive selective,covalent G12C ARS 853 inhibitor