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2,5-Di-tert-butylhydroquinone

Catalog No. T7540 CAS 88-58-4

Synonyms: BHQ

2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.

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2,5-Di-tert-butylhydroquinone Chemical Structure

2,5-Di-tert-butylhydroquinone, CAS 88-58-4

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100 mg	In stock	$ 41.00

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Purity: 98%

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Description	2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
Targets&IC50	Ca2+-ATPase:66.7 μM
In vitro	BHQ shifted the voltage dependence of the steady-state inactivation curve to more negative potentials by 7 mV in the mid-potential of the curve, without affecting the activation curve as well as the time course of I(Ca(L)) inactivation.?Preincubation of the cells either with 10 microM cyclopiazonic acid, a SERCA inhibitor, or with 3 mM diethyldithiocarbamate, an inhibitor of intracellular superoxide dismutase (SOD), did not modify BHQ inhibition of I(Ca(L)).?On the contrary, this effect was no longer evident when SOD (250 u ml(-1)) was added to the perfusion medium.?Either in the presence or in the absence of cells, BHQ gave rise to superoxide anion formation, which was markedly inhibited by the addition of SOD.At micromolar concentrations, BHQ inhibits vascular I(Ca(L)) by giving rise to the formation of superoxide anion which in turn impairs the channel function.

Synonyms	BHQ
Molecular Weight	222.32
Formula	C14H22O2
CAS No.	88-58-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mg/mL(44.98mM)

References and Literature

1. Fusi F , Saponara S , Gagov H , et al. 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+channel via superoxide anion generation [J]. British Journal of Pharmacology, 2001, 133(7):988-996.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Traditional Chinese Medicine Monomer Library Ion Channel Inhibitor Library Lipid Metabolism Compound Library Anti-Aging Compound Library Human Metabolite Library Anti-Obesity Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library

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Keywords

2,5-Di-tert-butylhydroquinone 88-58-4 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel Lipoxygenase COX Cyclooxygenase 2,5Ditertbutylhydroquinone Inhibitor LOX inhibit 2,5 Di tert butylhydroquinone BHQ inhibitor

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