Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,970.00 | |
50 mg | 8-10 weeks | $ 2,580.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively). |
Targets&IC50 | Pim1:0.018 nM (ki), Pim3:0.08 nM (ki), Pim2:0.11 nM (ki) |
In vitro | GNE-955 inhibits proliferation of MM.1S cells (IC50: 0.5 μM) after 72 hours treatment. GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65). It shows no effect on total BAD, S6 or 4EBP protein levels. |
Molecular Weight | 416.48 |
Formula | C22H24N8O |
CAS No. | 1527523-39-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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GNE-955 1527523-39-2 Chromatin/Epigenetic JAK/STAT signaling Pim GNE 955 GNE955 inhibitor inhibit