tetrahydrofolate — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1153	Trimethoprim	NIH 204,BW 56-72,NSC-106568	DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
	Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...
T7598	Calcium N5-methyltetrahydrofolate	NSC173328	Others , Antifolate
	Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers		Others , Antifolate
T29461	5-Methyltetrahydrofolate triglutamate	5-Me-Thf(glu)3
	5-Methyltetrahydrofolate triglutamate is a form of folic acid.
T8003	Methotrexate disodium		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T11103	DS18561882		Others
	DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063.		Others
T20339	7-Hydroxymethotrexate	NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962	Drug Metabolite
	7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin...		Drug Metabolite
T13516	5-Methyltetrahydrofolic acid	5-Methyl THF	Endogenous Metabolite
	5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid and a methylated derivate of tetrahydrofolate. It is the predominant natural dietary folate and the principal form of folate in plas...		Endogenous Metabolite
T24985	5-Monobutyl methotrexate	NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986
	5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of ...
T25374	Emofolin sodium	NSC139490,MeTHHF disodium,NSC-139490,NSC 139490
	Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition o...
T76131	Sarcosine oxidase
	Sarcosine oxidase (SAO) catalyzes the oxidative demethylation of sarcosine, producing glycine, H2O2, and 5,10-CH2-tetrahydrofolate, substances commonly utilized in biochemical reactions [1].
T69257	Methotrexate diethyl ester
	Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthes...
T37998	N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)
	N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1....
T69177	Methotrexate di-n-butyl ester
	Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synt...
T7730L	Aminopterin sodium	NSC739,NSC 739 [as the base],NSC-739
	Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affini...
T25079	Aminopterin N-hydroxysuccinimide ester	Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
	Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase...
T25981	Pralatrexate, (S)-
	Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T25980	Pralatrexate, (R)-
	Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T74009	1,1,3-Tribromoacetone
	1,1,3-Tribromoacetone is an impurity of Methotrexate [1]. Methotrexate is an antimetabolite and antifolate drug that blocks the enzyme dihydrofolate reductase, stopping the transformation of folic acid into tetrahydrofol...
T32705	Levomefolate magnesium	L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human ...