sub-g1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3S0218	Thonningianin A		Apoptosis , Others
	1. Thonningianin A has anti-cancer activities.2. Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor.3. Thonningianin A has antioxidant property, involves radical scavenging, anti-superox...		Apoptosis , Others
T7791	Iberdomide	CC-220	Apoptosis , Ligand for E3 Ligase
	Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).		Apoptosis , Ligand for E3 Ligase
T2S1396	3-O-Acetyloleanolic acid		Apoptosis
	3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.		Apoptosis
TN2400	Alpha-Terthienylmethanol		Others
	Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.		Others
T63917	Anticancer agent 67
	Anticancer agent 67 is a ciprofloxacin analogue, an anticancer agent that induces apoptosis and increases sub-G1 cell populations in MCF-7 cells.
T36944	Ara-G		Nucleoside Antimetabolite/Analog
	Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...		Nucleoside Antimetabolite/Analog
T74865	BK50164
	BK50164, a potent CD73 inhibitor, exhibits an IC50 of 13.089 µM and demonstrates affinity for CD99 with a KD value of 1.5 µM. This compound not only possesses antiproliferative activity but also induces apoptosis and cel...
T72479	Anticancer agent 66
	Anticancer agent 66, a ciprofloxacin analog, functions as an anti-cancer agent by inducing apoptosis and elevating the sub-G1 cell population in MCF-7 cells.
T63360	DNA topoisomerase II inhibitor 1
	DNA topoisomerase II inhibitor 1 is a potent inhibitor of DNA topoisomerase II that arrests the cell cycle in sub-G1 phase and induces apoptosis with anti-value-added effects.
T72411	Kobusine derivative-2
	Kobusine derivative-2, a kobusine derivative, exhibits antiproliferative activity against cancer cells, particularly by inducing the arrest of MDA-MB-231 cells in the sub-G1 phase, thus highlighting its potential antican...
TN3719	Cristacarpin		p38 MAPK , ROS , CDK , Antifection , p53
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which ev...		p38 MAPK , ROS , CDK , Antifection , p53
T78872	CTL-06
	CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating...
T78873	CTL-12
	CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apo...
T71287	CDKI-83
	CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determi...
T63528	HSP90-IN-11
	HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cel...
T70962	MHY219
	MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) whe...