sickle — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7581	Voxelotor	GBT 440	Others
	Voxelotor (GBT 440) is an inhibitor of sickle hemoglobin (HbS).		Others
T21652	RN-1 dihydrochloride		Histone Demethylase , MAO
	RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).		Histone Demethylase , MAO
T35044	Velaresol	BW 12C79,BW 12C,BW-12C79,BW12C79,BW-12C
	Velaresol (BW12C, BW12C79) is an oxygenated hemoglobin stabilizer that, in addition to stabilizing oxygenated hemoglobin, protects sickle cells from calcium-mediated dehydration.
T77399	Crizanlizumab	ADAKVEO,SEG-101	Others
	Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.		Others
T3528	Senicapoc	ICA-17043	Potassium Channel
	Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 =...		Potassium Channel
TN2719	2',4'-Dihydroxy-6'-methoxyacetophenone		Antibacterial
	2',4'-Dihydroxy-6'-methoxyacetophenone is a phenolic acetophenone extracted from Leguminosae and Asteraceae with antimicrobial activity and can be used in the synthesis of pyran-sickle.		Antibacterial
T8074	Esafosfan trisodium	Fosfructose trisodium,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others , Endogenous Metabolite
	Esafosfan trisodium (FDP trisodium) is a cytoprotective natural sugar phosphate for the potential treatment of sickle cell anemia, cardiovascular ischemia and asthma. It acts by stimulating anaerobic glycolysis which gen...		Others , Endogenous Metabolite
T21389	Enprofylline	Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum	Others
	Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick...		Others
T2044	Varespladib	LY315920	Phospholipase
	Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusiv...		Phospholipase
T61833	Tovinontrine	IMR-687	PDE
	Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits high efficacy, with IC 50 values of 8.19 nM and 9.99 nM fo...		PDE
T3228	Fosfructose	D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others , Endogenous Metabolite
	D-fructose-1,6-diphosphate (D-fructose-1,6-diphosphate), also known as Fosfructose, is a cytoprotective natural sugar phosphate. It functions by promoting anaerobic glycolysis, which generates adenosine triphosphate (ATP...		Others , Endogenous Metabolite
T16478	PF-04447943	PF 04447943,Edelinontrine,PF04447943	PDE
	PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits ...		PDE
T33730	N-Phenylacetylphenylalanine
	N-Phenylacetylphenylalanine is a biaromatic agent with properties that make them suitable candidates for the treatment of sickle cell disease.
T26095	Rivipansel	GMI1070,GMI-1070,PF 06460031,GMI 1070,PF-06460031
	Rivipansel is a glycomimetic compound. It acts as a pan-selectin antagonist and reverses acute vascular occlusions in sickle cell mice.
T39809	PRMT5-IN-14	PRMT5-IN-14
	PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
T71292	Rivipansel sodium
	Rivipansel sodium is a glycomimetic drug candidate that acts as a pan-selectin antagonist and reverses acute vascular occlusions in sickle cell mice.
T40154	FTX-6058
	FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for res...
T39441	L-Arginine-15N4 hydrochloride	L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride
	L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vaso...
T40155	FTX-6058 hydrochloride
	FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valu...
T70614	SLR080811 HCl
	SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h...