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RN-1 dihydrochloride

Catalog No. T21652 CAS 1781835-13-9

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).

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RN-1 dihydrochloride, CAS 1781835-13-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 393.00
50 mg	In stock	$ 618.00
100 mg	In stock	$ 879.00
500 mg	In stock	$ 1,790.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
Targets&IC50	LSD1:70 nM, MAO-A:0.51 μM, MAO-B:2.785 μM
In vitro	RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively[3].
In vivo	In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology[1]. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9[3].

Molecular Weight	452.42
Formula	C23H31Cl2N3O2
CAS No.	1781835-13-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 18 mg/mL (39.79 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Shuaiying Cui, et al. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16;126(3):386-96. 2. Sergiy Konovalov, et al. Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res. 2013 Oct 29;6(1):75. 3. Ramesh Neelamegam, et al. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Histone Modification Compound Library Bioactive Compounds Library Max Epigenetics Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Mitochondria-Targeted Compound Library

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LSD1-IN-24 DDP-38003 dihydrochloride CP2 GSK-J1 lithium salt Ryuvidine JMJD7-IN-1 GSK-J1 LSD1-IN-20

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RN-1 dihydrochloride 1781835-13-9 Chromatin/Epigenetic Metabolism Neuroscience Histone Demethylase MAO disease RN 1 dihydrochloride inhibit RN1 hemoglobin fetal RN1 dihydrochloride brain-penetrant LSD1 RN1 Dihydrochloride Inhibitor HbF sickle RN 1 Dihydrochloride cell irreversible RN 1 RN-1 RN-1 Dihydrochloride inhibitor

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