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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12787 | Ryanodine | Others | |
Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ rel... | |||
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T8815 | Azumolene | EU4093 free base | Calcium Channel |
Azumolene (EU4093 free base) | |||
T60127 | Chlorantraniliprole | Rynaxypyr,Chlorantranilipole,Rynaxpyr | Others |
Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine re... | |||
T37807 | JTV 519 fumarate | ||
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r... | |||
T4054 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene | Calcium Channel , Autophagy |
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t... | |||
T24239 | K201 | K-201,JTV 519,JTV-519,K 201 | Calcium Channel |
K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors. | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T80153 | Maurocalcine | Calcium Channel | |
Maurocalcine is a cell-permeable agonist for ryanodine receptor (RyR) subtypes 1, 2, and 3. It enhances [3 H]ryanodine binding to RyR1 with an EC50 of 2558 nM and demonstrates an apparent affinity for RyR2 at 14 nM. This... | |||
T32855 | Lomifylline | Cervilane | |
Lomifylline is an inducer that induces the release of Ca2+ stored in cells, specifically through the ryanodine receptor. | |||
T81236 | RyRs activator 5 | ||
Compound A-1 (RyRs activator 5) is an efficacious agonist of ryanodine receptors, exhibiting activity against Spodoptera frugiperda [1]. | |||
T11732 | JTV-519 hemifumarate | K201 hemifumarate | MELK |
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. | |||
T68886 | FLA-365 | ||
FLA-365 is a biochemical that has been shown to inhibit ryanodine-enhanced calcium release from skeletal SR vesicles in a dose-dependent manner. | |||
T34458 | Ryanodol | ||
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission. | |||
T72004 | Azumolene sodium anhydrous | ||
Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus... | |||
T80039 | ATX-II | Sodium Channel | |
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [... | |||
T82936 | ATX-II TFA | Sodium Channel | |
ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in... | |||
T68366 | Azumolene sodium dihydrate | ||
Azumolene sodium dihydrate is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus... | |||
T19253 | Cyclic ADP-ribose | cADPR | Calcium Channel |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med... | |||
T11731 | JTV-519 free base | K201 free base | FLT |
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partia... |