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Search Results for " ryanodine "

20

Compounds

Cat No. Product Name Synonyms Targets
T12787 Ryanodine Others
Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ rel...
T8452 Dantrolene Others
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
T8815 Azumolene EU4093 free base Calcium Channel
Azumolene (EU4093 free base)
T60127 Chlorantraniliprole Rynaxypyr,Chlorantranilipole,Rynaxpyr Others
Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine re...
T37807 JTV 519 fumarate
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r...
T4054 Dantrolene sodium hemiheptahydrate Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene Calcium Channel , Autophagy
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t...
T24239 K201 K-201,JTV 519,JTV-519,K 201 Calcium Channel
K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors.
T4973 Paraxanthine 1,7-DIMETHYLXANTHINE Endogenous Metabolite
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...
T80153 Maurocalcine Calcium Channel
Maurocalcine is a cell-permeable agonist for ryanodine receptor (RyR) subtypes 1, 2, and 3. It enhances [3 H]ryanodine binding to RyR1 with an EC50 of 2558 nM and demonstrates an apparent affinity for RyR2 at 14 nM. This...
T32855 Lomifylline Cervilane
Lomifylline is an inducer that induces the release of Ca2+ stored in cells, specifically through the ryanodine receptor.
T81236 RyRs activator 5
Compound A-1 (RyRs activator 5) is an efficacious agonist of ryanodine receptors, exhibiting activity against Spodoptera frugiperda [1].
T11732 JTV-519 hemifumarate K201 hemifumarate MELK
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
T68886 FLA-365
FLA-365 is a biochemical that has been shown to inhibit ryanodine-enhanced calcium release from skeletal SR vesicles in a dose-dependent manner.
T34458 Ryanodol
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T72004 Azumolene sodium anhydrous
Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus...
T80039 ATX-II Sodium Channel
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [...
T82936 ATX-II TFA Sodium Channel
ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in...
T68366 Azumolene sodium dihydrate
Azumolene sodium dihydrate is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus...
T19253 Cyclic ADP-​ribose cADPR Calcium Channel
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med...
T11731 JTV-519 free base K201 free base FLT
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partia...
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