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Search Results for " repolarization "

10

Compounds

Cat No. Product Name Synonyms Targets
T7776 ADH-503 GB1275 Complement System
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
T1676 Rosuvastatin ZD 4522 Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...
T1510 Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T13379 (Z)-Leukadherin-1 ADH-503 free base Complement System
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
T7195 GSK369796 Dihydrochloride N-tert-butylisoquine Potassium Channel , Parasite
GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)
T14077 A-935142 EGFR
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. a-935142 enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, shortening atrial and ventricular re...
T6476 Dofetilide UK 68789,UK-68798,Tikosyn Potassium Channel
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik...
T16444 PD-118057 Potassium Channel , HER
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential ...
T25934 Pentisomide Pentisomidum
Pentisomide is a class-I antiarrhythmic agent with a marked effect on depolarization (action of class Ia and Ic) and on repolarization. Pentisomide dose-dependently inhibited ischaemia-reperfusion arrhythmia. Pentisomide...
T36561 (3S)-hydroxy Quinidine
(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 be...
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