Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 213.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 628.00 | |
50 mg | In stock | $ 997.00 | |
100 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 235.00 |
Description | PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure. |
In vitro |
PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.[1][2]
PD-118057 (10 μM) counteracts the current inhibition triggered by Dof and Mox while preserving the unaltered 'hump' shape of the IKr current and exhibiting only a marginal increase in the maximum value of the suppressed current.[2] |
Molecular Weight | 386.27 |
Formula | C21H17Cl2NO2 |
CAS No. | 313674-97-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (233.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PD-118057 313674-97-4 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors HER Potassium Channel PD118057 PD 118057 inhibitor inhibit